2013-01-08: Symposium "Molecular Oncology - present achievements and future directions"
MOMA holds an international symposium "Molecular Oncology" on the occasion of prof. Torben Falck Ørntoft's 60th-birthday on January, 24th at 12.30-15 at Aarhus University Hospital Skejby.
2012-12-20: MOMA's research in biomarkers in prostate cancer funded by The Danish National Advanced Technology Foundation
A new way of diagnosing prostate cancer and its aggressiveness by biomarkers in eg. urine should lead to fewer prostatectomies.
Read more (Danish).
2012-09-27: Job vacancy
A two-year post doc position in molecular prostate cancer research at MOMA is available. Application deadline: October, 7th 2012.
2012-09-26: MOMA has received major funding
The Danish Council for Independent Research funds an upcoming project using pig animal models with DKK 5.85 mill. (appr. 780,000 Euros).
Project titel: "The cell community in bladder and colon cancer; studies in clinical specimens and an animal model for identification of metastatic and treatment resistant cell populations"
2012-07-11: Job vacancy
A three-year post doc position in cancer genomics in the bioinformatics group at MOMA is available. Application deadline: September, 3rd 2012.
2012-04-26: Paper receives award
The EAU Section of Oncological Urology (ESOU) congress 2012 in Hamburg has awarded our recent paper in Am J Pathol to the best published paper in Urologic Oncology.
Per-Uno Malmström acccepted the prize as a representative of the author group.
Fristrup N, Ulhøi BP, Birkenkamp-Demtröder K, Mansilla F, Sanchez-Carbayo M, Segersten U, Malmström PU, Hartmann A, Palou J, Alvarez-Múgica M, Zieger K, Borre M, Orntoft TF, Dyrskjøt L.
Cathepsin E, Maspin, Plk1, and Survivin Are Promising Prognostic Protein Markers for Progression in Non-Muscle Invasive Bladder Cancer.
Am J Pathol. 2012 May;180(5):1824-34. Epub 2012 Mar 24
2011-12-29: Next Generation Sequencing Core Center Inauguration
MOMA offers next generation sequencing services to users from hospitals and universities at our newly established core facility.
MOMA NGS Core Center will hold an opening symposium for all interested parties on January, 12th 2012.
2011-12-20: Job vacancy
A three-year postdoc position in molecular colorectal cancer research is available for application.
Title: "Development of personalized tumor biomarkers for disease monitoring using massive paralleled sequencing."
Application deadline: January, 18th 2012.
See job announcement.
2011-11-15: Job vacancy
A three-year PhD position in bioinformatics with focus on prostate cancer is open for application.
Title: "Development of integrative data analysis methods and data visualizations tools to identify clinically relevant molecular changes in prostate cancer: a systems biology approach"
Application deadline: November, 28th 2011.
See job announcement.
2011-09-27: MolPros website launched
Molecular Prediction of Prostate Cancer Risk and Aggressiveness (MolPros) is an inter-disciplinary translational cancer research alliance bringing together experts from Denmark, Germany, China and USA.
MolPros is a 4-year project (2011-2014) supported by a grant (~2 mil. Euros, 14.5 mil. DKK) from the Danish Council for Strategic Research and co-financed (~1 mil. Euros, 7 mil. DKK) by the involved partners.
Read more at molpros.dk
2011-09-21: Prof. Torben Ørntoft novel elected Fellow of EACS
The European Academy of Cancer Sciences has elected 25 new Fellows by online voting, bringing the number of members up to 164. Prof. Torben F. Ørntoft is the 5th member in Denmark - a life long distinction - specialising in Translational Molecular Research.
Fellows of the Academy will contribute to the preparation of position papers, interact with the EU institutions and the ECCO Policy Committee to facilitate proposals and help the implementation process of new policies in order to ensure that cancer research remains at the top of the European cancer health and research policy agenda.
2011-06-23: Job vacancies
MOMA has 2 vacant postdoc positions:
Postdoc in molecular prostate cancer research (extended application deadline September, 12th 2011)
Post doc in transcriptome-wide RNA structure analysis (application deadline August, 15th 2011)
2011-04-08: Blood screening method for colon cancer presented at AACR 102nd meeting
Positive results in 4-year project partly funded by the "Danish National Advanced Technolgy Foundation" will be published by Exiqon A/S later this year.
The project "Early detection of colon cancer in blood samples" uses miRNA as a screening tool in less than 200 µl blood.
Project partners are Exiqon A/S, Hvidovre Hospital, KU – LIFE and Aarhus Universitetshospital (Dept. of Molecular Medicine). The budget is 42 mill. Danish Kroner (about 5.6 mill. Euro).
2011-04-05: PhD scholarship announcement
A three-year PhD scholarship in Molecular Bladder Cancer Research is available.
Application deadline: April 28th, 2011
Read announcement (pdf)
2011-03-03: MOMA in project "Systems Biology of Colorectal Cancer (SYSCOL)"
Professor Torben F. Ørntoft and associate professor Claus Lindbjerg Andersen lead MOMA's participation in the SYSCOL project funded under the EU 7th Framework Programme by 12 million Euros with participating research groups from 10 countries.
SYSCOL uses the tools of systems biology to develop a quantitative and comprehensive model of colorectal tumourigenesis. The model will include a wiring diagram that identifies cell-type specific and oncogenic pathways that contribute to colon tumourigenesis, and explains in molecular detail how a genotype of an individual CRC leads to activation of downstream genes that drive uncontrolled cell growth.
European Commission CORDIS
Udvikling af kræftsygdom skal kortlægges i alle detajler (Danish, skejby.dk)
Press release (Danish)
2010-12-10: New genetic test to support early and precise diagnosis of prostate cancer
MOMA will implement a large 4-year research project to reduce the unnecessary use of PSA-testing and overtreatment of prostate cancer among Danish patients.
Read more (in Danish)
News on dr.dk
2010-10-05: Cell Line Authentication service available
MOMA announces IdentiCell - a service to authenticate cell lines by STR-profiling.
The authentication of cell lines used in scientific research is of obvious importance. About 15% of cell lines are misidentified or cross-contaminated. Use our high-quality service to authenticate your cell lines before publication, grant-application or costly projects.
For more details see flyer (pdf) or visit us at identicell.eu
research will improve prostate cancer therapy
when a patient is diagnosed with prostate cancer for the clinicians
it can be difficult to predict the aggressiveness of the disease.
The Danish Cancer Society cooperates with and funds the prostate
cancer research group at the Dept. of Molecular Medicine, Aarhus
University Hospital, Skejby with 1.8 mill Danish kroner to identify
molecular markers for aggressiveness of the prostate cancer of the
individual patient that eventually can help with clinical decision
more (in Danish)
Danish National Advanced Technology Foundation supports two projects
In 2010 the foundation invests 286 millions Danish
kroner in 19 projects and platforms, the largest investement in
the five years the foundation has existed.
The two projects involve the scientific expertise of researchers
at MDL to develop software to diagnose DNA-bases diseases and to
use large numbers of archival formalin-fixed paraffine-embedded
tissue samples on the next-generation sequencing platform for gene
bio heading $2M project to develop molecular diagnostics solution
løsning skal kunne diagnosticere DNA-baserede sygdomme
Millioner af vævsprøver
kan revolutionere sygdomsbehandling
Fundings from The Danish Cancer Society
research projects at MDL have received fundings of 7.45 mill Danish
The fundings run from 2011 to 2013 and support projects in bladder
and prostate cancer. Out of 202 applications 56 projects have been
funded with 74 mill Danish kroner by the scientific board of the
Danish Cancer Society.
The 3 projects at MDL are:
Molecular changes in clinical bladder cancer.
Professor Torben Falck Ørntoft
Department of Molecular Medicine, Aarhus University Hospital Skejby
Identification of genetic and epigenetic biomarkers for prostate
Ass. prof., ph.d. Karina Dalsgaard Sørensen
Department of Molecular Medicine, Aarhus University Hospital Skejby
Identification and characterization of circulating exosomes in
bladder cancer patients with focus on mRNA and non-coding RNA.
MSc, PhD Marie Stampe Ostenfeld
Department of Molecular Medicine, Aarhus University Hospital Skejby
Vacant positions postdocs/assistant professor
Several academic positions (full-time) as researcher in molecular
clinical cancer research are available at MDL. Application deadline
September, 6th 2009.
Read full job announcement.
for bladder and prostate cancer positions.
for colon cancer positions.
Vacant position administrator
MDL offers a vacant position as an all-round research administrator,
application deadline August 31, 2009.
MDL is granted a 19.5 million Danish Kroner appropriation
gladly announce that CMCC, The
John and Birthe Meyer Cancer Center for Molecular and Clinical Cancer
Research under the Dept. of Molecular Medicine, has received a major
grant from the Meyer Foundation which assures continuation of our
high-standard cancer research for the next five years.
CMCC's research focuses on molecular classification of cancer patients
at high risk of disease and identification of patients with the
most agressive tumours. To achieve this, the newest molecular technologies
and extensive biobanks are applied.
We are happy to note a frequent use of our NormFinder software
and a high number of inquiries. Therefore, we have updated the NormFinder
documentation (v19) and created a sample data set, which better
illustrates the use of the NormFinder software.
We hope to have answered frequently asked questions about group
identifiers, data sheet organisation and evaluation of top ranked
If you need more help, please use the information on the NormFinder
research on "Cancer Research" cover
Associated professor Lars Dyrskjøt, who recently won a prize
being "The most publishing researcher aged under 40 at Skejby
Hospital", led the work on miRNAs in bladder cancer resulting
in this publication:
profiling of microRNAs in bladder cancer: miR-129 is associated
with poor outcome and promotes cell death in vitro. Dyrskjøt
L, Ostenfeld MS, Bramsen JB, Silahtaroglu AN, Lamy P, Ramanathan
R, Fristrup N, Jensen JL, Andersen CL, Zieger K, Kauppinen S, Ulhøi
BP, Kjems J, Borre M, Orntoft TF. Cancer Res. 2009 Jun 1;69(11):4851-60.
more (in Danish).
coverage by regional TV (Danish).
The official opening of the novel Department
of Molecular Medicine (MOMA) at Aarhus University Hospital Skejby
takes place at March, 11th 2009.
MDL will be hosting a two-day symposium "Molecular Oncology"
mainly aimed at PhD students and Postdocs in molecular cancer research
to celebrate the inauguration of MOMA at March 12-13th, 2009.
MDL is moving
december 2008 MDL will move to new locations at the Science Center
Skejby (former residence of the newspaper Århus Stifstidende)
nearby and belong to the new Department of Molecular Medicine (MOMA)
at the Århus University Hospital Skejby.
The official opening will take place in march 2009.
MDL is going to enjoy spacious and modern facilities, which make
room for state-of-the-art equipment and provide stimulating working
surroundings for the staff.
New phone numbers from 16-12-2008:
Laboratory +45 8949 9430
Secretary +45 8949 9410
more about MOMA (Dept. of Molecular Medicine) in Danish
MDL's gentest for laktoseintolerans omtalt i Ugeskrift for Læger
Mælkesukkerproblemer kan nu nemt bestemmes i en blodprøve
Mangelfuld optagelse af mælkesukker kan give luft i maven,
mavesmerter og diare. Tidligere var det besværligt at teste
personer for, om de havde problemer med mælkesukkeroptagelsen,
men nu har forskerne fundet det gen, der bevirker, at man får
disse problemer, og derfor kan det gøres ved en simpel blodprøve.
af laktoseintolerans hos voksne
Laktoseintolerans - mælk og molekylærbiologi
Speciale Studerende i Kræftforskning
Hos Molekylær Diagnostisk Laboratorium, Klinisk Biokemisk
Afdeling, Skejby Sygehus arbejder vi med molekylær karakteristik
af blære-, prostata- og tarmkræft. Målet med forskningen
er at opnå en molekylær klassifikation af sygdommene
for dermed at kunne give en mere optimal behandling af patienterne.
Desuden er målet at opnå en større forståelse
af sygdommenes molekylære forhold i aktive pathways og i relation
til sygdomsforløb og behandlingsrespons.
Projektet vil tage udgangspunkt i molekylære forandringer
i tumorvæv som har en klinisk relevans. Det kan f.eks. være
microRNA eller mRNA transkript profiler som er relateret til udvikling
af metastaser eller respons på kemoterapi. Projektet vil bl.a.
involvere immunhistokemiske analyser, overudtryks- eller knockdown
analyser såvel som funktionelle assays til måling af
f.eks. apoptose, proliferation og invasionspotentiale efter in vitro
overudtryk eller knockdown af relevante molekyler. Relevante molekyler
vil blive udvalgt til klinisk afprøvning.
Er du interesseret i at lave speciale inden for kræftforskning
og indgå i et spændende forskermiljø så
kontakt Karin Demtröder på tlf. 8949-5119 eller Professor
Torben Ørntoft på tlf. 8949-5100.
Du kan læse mere om vores aktuelle forskning på www.mdl.dk
Du kan læse mere her Her
Gentest forudsiger skæbnen for blærekræftpatienter
|| Forskere fra Skejby Sygehus
har udviklet en genchip, som kan afsløre, hvor slemt
blærekræftpatienter er ramt af deres sygdom. Det
viser en ny undersøgelse, hvor fire lande udover Danmark
har deltaget. Et stort skridt på vejen til, at chippen
kan blive en naturlig del af hospitalsgangen og hjælpe
til, at blærekræftpatienter får den bedste
og mest nænsomme behandling.
|Læs den fulde
2007-03-19: Updated Request Form
The request form for diagnostic genetical analysises has been updated
to version 8, please download from
MDL 10-year anniversary
On May, 1st 1997 MDL was officially founded. The 10-year anniversary
will be celebrated on April, 27th.
2007-02-26: Updated Request Form
The request form for diagnostic genetical analysises has been updated,
please download from
2007-02-21: Vacant positions
MDL has three open postdoc positions (3-years) in Clinical Molecular
Cancer Research. Applicants will be evaluated by a review committee
at Aarhus University, The Faculty of Health Sciences.
job announcements (Danish)
Application deadline: March 19th, 2007
2006-12-04: Cells get old fighting cancer
International cooperation, led by the known researchers and spouses
Jirina Bartkova and Jiri Bartek at The Danish Cancer Society, Copenhagen,
and with Danish scientists from The Danish Cancer Society, MDL and
Rigshospitalet resulted in another publication in the recognized
Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas
D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC,
Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M,
Andersen CL, Dyrskjot L, Orntoft T, Lukas J, Kittas C, Helleday
T, Halazonetis TD, Bartek J, Gorgoulis VG.
Oncogene-induced senescence is part of the tumorigenesis barrier
imposed by DNA damage checkpoints. Nature. 2006 Nov 30;444(7119):633-7.
more (in Danish) at the The Danish Cancer Society website.
2006-09-27: Vacant position
for molecular biologist
MDL seeks a molecular biologist full-time (37 h/week). Application
deadline: 16th October 2006. Read
See job announcement
2006-07-27: New research results within
colorectal cancer therapy
MDL contributed to results published in Nature Genetics,
that inflict the therapy of colorectal cancer with HDAC inhibitors.
In the future, an individual test for a certain mutation can decide
if HDAC-inhibition therapy is useful or not.
Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H,
Boix-Chornet M, Caballero R, Alaminos M, Setien F, Paz MF, Herranz
M, Palacios J, Arango D, Orntoft TF, Aaltonen LA, Schwartz S, Esteller
M. A truncating mutation of HDAC2 in human cancers confers
resistance to histone deacetylase inhibition. Nat Genet. 2006 May;38(5):566-9.
Epub 2006 Apr 16. PubMed
this in Danish
2006-06-28: MDL seeks
The prostate cancer group at MDL seeks a graduate student (molecular
biology) for a master thesis project from September, 1st 2006:
"Characterization of a new tumour suppressor gene candidate
in prostate cancer by overexpression, siRNA knock-down and microarray
2006-05-17: MDL offers a new genetic analysis
A mutation screen for adult–type hypolactasia (LCT -13910C>T)
is offered in MDL's panel of diagnostic
services. Please refer to the Dep.
of Clinical Biochemistry for further information. A new requisition
form can be downloaded.
MDL participates in ”The MicroRNA Research
Consortium – Towards novel molecular targets for LNA-based
High Technology Fund under the Ministry of Science has granted
10 million Danish Kroner for the development of diagnostic techniques
to measure microRNA. The consortium consists of The University of
Copenhagen, Aarhus University Hospital (MDL), Bioneer, Exiqon, Visiopharm
and Novo Nordisk including Steno Diabetes Center. Together with
the investements of the participants the budget will be 32 million
Danish Kroner over three years. A kick-off meeting will be held
more (in Danish)...
2006-01-24: MDL comments on breakthrough
in prostate cancer research
American researchers have published results in Science
that show chromosomal changes in 80% of prostate cancer patients,
a fusion of the TMPRSS2 and ETS transcription factor genes. These
results have implications in the development of carcinomas and the
molecular diagnosis and treatment of prostate cancer.
Niels Tørring, Ph.d. and leader of MDL's prostate cancer
research group comments on the website of the Danish
Cancer Society (in Danish).
2005-11-11: MDL passes
German External Quality Assessment scheme with full marks
MDL participated in an External
Quality Assessment (EQA) program for molecular diagnostics of HNPCC
2005 in Bonn and München, Germany. Participants included
12 German members of "Berufsverband
Deutscher Humangenetiker e.V." and HNPCC centres supported
by the German Cancer Aid as well as four laboratories from abroad.
Nine laboratories including MDL achieved the maximum 18 points for
mutational analysis by sequencing, MLPA and DHPLC, interpretation
and written report to the counselling physician evaluating the results
and diagnostics possibilities/recommendation for family members
of the screened patient.
2005-08-22: GEO data available
our microarray raw data directly for selected publications using
the GENE EXPRESSION
OMNIBUS (GEO) database at NCBI.
See under supplementary data.
MDL in "Augustus"
MDL's research is covered by an article in the latest
issue of Århus University's alumne magazine "Augustus"
(page 20, in Danish).
2005-05-23: Prof. T. Ørntoft receives
"Consul Ernst Carlsen Honorary Award" of 60.000 Danish
Kroner for excellent cancer research and humanitarian achievements,
carried out by prof. Torben Ørntoft and his research group
at MDL, was given to prof. Torben Ørntoft at monday. The
award is granted by a committee consisting of representatives from
Read more in Danish...
2005-04-14: Research results
from MDL on "Nature" cover
Danish cancer researchers from The Danish Cancer Society,
MDL and researchers from Institutes in Norway and the Czech Republic
have published the articel: "DNA
damage response as a candidate anti-cancer barrier in early human
tumorigenesis" in the recognized scientific journal "Nature"
See also comments in 'News and Views' in the same issue: "Aborting
the birth of cancer".
Read more (in Danish) from Aarhus
University Hospital, The
Danish Cancer Society and see this news on the Danish
|2005-04-04: Request form for
To order genetic analysis service, please
use this request
form (in Danish).
Center for Molecular Cancer Research
a John and Birthe Meyer Cancer Center, will be officially opened at
March, 3rd at the Science Park at Skejby Hospital.
A new version of NormFinder for R and version 0.953 of the MS Excel
add-in are now available for direct download.
|2004-11-02: Job announcements
MDL has vacant positions in Clinical Molecular Cancer Research as
researcher or group leader.
Application deadline is by November, 19th, 2004.
|2004-08-23: NormFinder software
- a new MS Excel add-in for normalization of real-time quantitative
RT-PCR data developed by MDL.
|2004-08-10: Symposium announcement
The Third Symposium on Array Technology in Research and Diagnostics
will be held from October, 29th to 30th, 2004 at the Aarhus University
|2004-06-22: MDL receives major funding
MDL has received a major donation of The John and Birthe Meyer Foundation
of 19.8 million Danish Kroner (about 2,6 mill. Euro) to strengthen
and enhance its research in bladder, colon and prostate cancer. A
new Center for Molecular Clinical Cancer
Research will be founded at Aarhus University Hospital at Skejby
in January 2005. MDL will cooperate with clinical and surgical departments
from different hospitals as well as research laboratories at Aarhus
University to gather and investigate numerous tumor samples. Read
this in Danish