Molecular Diagnostic Laboratory
Department of Molecular Medicine,
Aarhus University Hospital Skejby

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2013-01-08: Symposium "Molecular Oncology - present achievements and future directions"

MOMA holds an international symposium "Molecular Oncology" on the occasion of prof. Torben Falck Ørntoft's 60th-birthday on January, 24th at 12.30-15 at Aarhus University Hospital Skejby.

See programme.

2012-12-20: MOMA's research in biomarkers in prostate cancer funded by The Danish National Advanced Technology Foundation

Prostate CancerA new way of diagnosing prostate cancer and its aggressiveness by biomarkers in eg. urine should lead to fewer prostatectomies.

Read more (Danish).

2012-09-27: Job vacancy

A two-year post doc position in molecular prostate cancer research at MOMA is available. Application deadline: October, 7th 2012.

Read more.

2012-09-26: MOMA has received major funding

DFFThe Danish Council for Independent Research funds an upcoming project using pig animal models with DKK 5.85 mill. (appr. 780,000 Euros).

Project titel: "The cell community in bladder and colon cancer; studies in clinical specimens and an animal model for identification of metastatic and treatment resistant cell populations"

Read more.

2012-07-11: Job vacancy

A three-year post doc position in cancer genomics in the bioinformatics group at MOMA is available. Application deadline: September, 3rd 2012.

Read more.

2012-04-26: Paper receives award

ESOU 2012The EAU Section of Oncological Urology (ESOU) congress 2012 in Hamburg has awarded our recent paper in Am J Pathol to the best published paper in Urologic Oncology.

Per-Uno Malmström acccepted the prize as a representative of the author group.

Fristrup N, Ulhøi BP, Birkenkamp-Demtröder K, Mansilla F, Sanchez-Carbayo M, Segersten U, Malmström PU, Hartmann A, Palou J, Alvarez-Múgica M, Zieger K, Borre M, Orntoft TF, Dyrskjøt L.
Cathepsin E, Maspin, Plk1, and Survivin Are Promising Prognostic Protein Markers for Progression in Non-Muscle Invasive Bladder Cancer.
2012 May;180(5):1824-34. Epub 2012 Mar 24

 

2011-12-29: Next Generation Sequencing Core Center Inauguration

MOMA offers next generation sequencing services to users from hospitals and universities at our newly established core facility.

MOMA NGS Core Center will hold an opening symposium for all interested parties on January, 12th 2012.

Invitation

Read more.

2011-12-20: Job vacancy

A three-year postdoc position in molecular colorectal cancer research is available for application.

Title: "Development of personalized tumor biomarkers for disease monitoring using massive paralleled sequencing."

Application deadline: January, 18th 2012.

See job announcement.

2011-11-15: Job vacancy

A three-year PhD position in bioinformatics with focus on prostate cancer is open for application.

Title: "Development of integrative data analysis methods and data visualizations tools to identify clinically relevant molecular changes in prostate cancer: a systems biology approach"


Application deadline: November, 28th 2011.

See job announcement.

Read more.

2011-09-27: MolPros website launched

MolProsMolecular Prediction of Prostate Cancer Risk and Aggressiveness (MolPros) is an inter-disciplinary translational cancer research alliance bringing together experts from Denmark, Germany, China and USA.

MolPros is a 4-year project (2011-2014) supported by a grant (~2 mil. Euros, 14.5 mil. DKK) from the Danish Council for Strategic Research and co-financed (~1 mil. Euros, 7 mil. DKK) by the involved partners.

Read more at molpros.dk

 

2011-09-21: Prof. Torben Ørntoft novel elected Fellow of EACS

Torben ØrntoftEACSThe European Academy of Cancer Sciences has elected 25 new Fellows by online voting, bringing the number of members up to 164. Prof. Torben F. Ørntoft is the 5th member in Denmark - a life long distinction - specialising in Translational Molecular Research.

Fellows of the Academy will contribute to the preparation of position papers, interact with the EU institutions and the ECCO Policy Committee to facilitate proposals and help the implementation process of new policies in order to ensure that cancer research remains at the top of the European cancer health and research policy agenda.

Read more.

2011-06-23: Job vacancies

MOMA has 2 vacant postdoc positions:

Postdoc in molecular prostate cancer research (extended application deadline September, 12th 2011)

Post doc in transcriptome-wide RNA structure analysis (application deadline August, 15th 2011)

 

2011-04-08: Blood screening method for colon cancer presented at AACR 102nd meeting

Positive results in 4-year project partly funded by the "Danish National Advanced Technolgy Foundation" will be published by Exiqon A/S later this year.
The project "Early detection of colon cancer in blood samples" uses miRNA as a screening tool in less than 200 µl blood.
Project partners are Exiqon A/S, Hvidovre Hospital, KU – LIFE and Aarhus Universitetshospital (Dept. of Molecular Medicine). The budget is 42 mill. Danish Kroner (about 5.6 mill. Euro).

Read more.

2011-04-05: PhD scholarship announcement

A three-year PhD scholarship in Molecular Bladder Cancer Research is available.
Application deadline: April 28th, 2011

Read announcement (pdf)

Jobindex announcement

2011-03-03: MOMA in project "Systems Biology of Colorectal Cancer (SYSCOL)"

FP7Professor Torben F. Ørntoft and associate professor Claus Lindbjerg Andersen lead MOMA's participation in the SYSCOL project funded under the EU 7th Framework Programme by 12 million Euros with participating research groups from 10 countries.

SYSCOL uses the tools of systems biology to develop a quantitative and comprehensive model of colorectal tumourigenesis. The model will include a wiring diagram that identifies cell-type specific and oncogenic pathways that contribute to colon tumourigenesis, and explains in molecular detail how a genotype of an individual CRC leads to activation of downstream genes that drive uncontrolled cell growth.

Read more:
European Commission CORDIS
Udvikling af kræftsygdom skal kortlægges i alle detajler (Danish, skejby.dk)
Press release (Danish)

2010-12-10: New genetic test to support early and precise diagnosis of prostate cancer

MOMA will implement a large 4-year research project to reduce the unnecessary use of PSA-testing and overtreatment of prostate cancer among Danish patients.
Read more (in Danish)

News on dr.dk

2010-10-05: Cell Line Authentication service available

MOMA announces IdentiCell - a service to authenticate cell lines by STR-profiling.

IdentiCellThe authentication of cell lines used in scientific research is of obvious importance. About 15% of cell lines are misidentified or cross-contaminated. Use our high-quality service to authenticate your cell lines before publication, grant-application or costly projects.

For more details see flyer (pdf) or visit us at identicell.eu

2010-06-25: Novel research will improve prostate cancer therapy

Today, when a patient is diagnosed with prostate cancer for the clinicians it can be difficult to predict the aggressiveness of the disease.
The Danish Cancer Society cooperates with and funds the prostate cancer research group at the Dept. of Molecular Medicine, Aarhus University Hospital, Skejby with 1.8 mill Danish kroner to identify molecular markers for aggressiveness of the prostate cancer of the individual patient that eventually can help with clinical decision making.

Read more (in Danish)

2010-06-03: The Danish National Advanced Technology Foundation supports two projects at MDL

In 2010 the foundation invests 286 millions Danish kroner in 19 projects and platforms, the largest investement in the five years the foundation has existed.

The two projects involve the scientific expertise of researchers at MDL to develop software to diagnose DNA-bases diseases and to use large numbers of archival formalin-fixed paraffine-embedded tissue samples on the next-generation sequencing platform for gene analysis.

Press releases:

CLC bio heading $2M project to develop molecular diagnostics solution

Dansk løsning skal kunne diagnosticere DNA-baserede sygdomme

Millioner af vævsprøver kan revolutionere sygdomsbehandling

2010-05-05: Fundings from The Danish Cancer Society

3 research projects at MDL have received fundings of 7.45 mill Danish kroner.

The fundings run from 2011 to 2013 and support projects in bladder and prostate cancer. Out of 202 applications 56 projects have been funded with 74 mill Danish kroner by the scientific board of the Danish Cancer Society.

The 3 projects at MDL are:

Molecular changes in clinical bladder cancer.
Professor Torben Falck Ørntoft
Department of Molecular Medicine, Aarhus University Hospital Skejby
4.300.000 kr.

Identification of genetic and epigenetic biomarkers for prostate cancer.
Ass. prof., ph.d. Karina Dalsgaard Sørensen
Department of Molecular Medicine, Aarhus University Hospital Skejby
1.800.000 kr.

Identification and characterization of circulating exosomes in bladder cancer patients with focus on mRNA and non-coding RNA.
MSc, PhD Marie Stampe Ostenfeld
Department of Molecular Medicine, Aarhus University Hospital Skejby
1.350.000 kr.

2009-07-06: Vacant positions postdocs/assistant professor

Several academic positions (full-time) as researcher in molecular clinical cancer research are available at MDL. Application deadline September, 6th 2009.

Read full job announcement.

Project descriptions for bladder and prostate cancer positions.

Project descriptions for colon cancer positions.

2009-06-25: Vacant position administrator

MDL offers a vacant position as an all-round research administrator, application deadline August 31, 2009.

Read more (Danish).

2009-06-24: MDL is granted a 19.5 million Danish Kroner appropriation

cmccWe gladly announce that CMCC, The John and Birthe Meyer Cancer Center for Molecular and Clinical Cancer Research under the Dept. of Molecular Medicine, has received a major grant from the Meyer Foundation which assures continuation of our high-standard cancer research for the next five years.

CMCC's research focuses on molecular classification of cancer patients at high risk of disease and identification of patients with the most agressive tumours. To achieve this, the newest molecular technologies and extensive biobanks are applied.

Read more (Danish).

2009-06-15: NormFinder software

We are happy to note a frequent use of our NormFinder software and a high number of inquiries. Therefore, we have updated the NormFinder documentation (v19) and created a sample data set, which better illustrates the use of the NormFinder software.

We hope to have answered frequently asked questions about group identifiers, data sheet organisation and evaluation of top ranked normalisation genes.

If you need more help, please use the information on the NormFinder page.

2009-05-31: MDL research on "Cancer Research" cover

Associated professor Lars Dyrskjøt, who recently won a prize being "The most publishing researcher aged under 40 at Skejby Hospital", led the work on miRNAs in bladder cancer resulting in this publication:

crGenomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro. Dyrskjøt L, Ostenfeld MS, Bramsen JB, Silahtaroglu AN, Lamy P, Ramanathan R, Fristrup N, Jensen JL, Andersen CL, Zieger K, Kauppinen S, Ulhøi BP, Kjems J, Borre M, Orntoft TF. Cancer Res. 2009 Jun 1;69(11):4851-60.

Read more (in Danish).

See coverage by regional TV (Danish).

2009-01-27: MOMA opening

The official opening of the novel Department of Molecular Medicine (MOMA) at Aarhus University Hospital Skejby takes place at March, 11th 2009.

MDL will be hosting a two-day symposium "Molecular Oncology" mainly aimed at PhD students and Postdocs in molecular cancer research to celebrate the inauguration of MOMA at March 12-13th, 2009.

pdf invitation

pdf program

2008-11-19: MDL is moving

Science Center SkejbyIn december 2008 MDL will move to new locations at the Science Center Skejby (former residence of the newspaper Århus Stifstidende) nearby and belong to the new Department of Molecular Medicine (MOMA) at the Århus University Hospital Skejby.
The official opening will take place in march 2009.

MDL is going to enjoy spacious and modern facilities, which make room for state-of-the-art equipment and provide stimulating working surroundings for the staff.

New phone numbers from 16-12-2008:

Laboratory +45 8949 9430
Secretary +45 8949 9410

Read more about MOMA (Dept. of Molecular Medicine) in Danish

2008-10-14: MDL's gentest for laktoseintolerans omtalt i Ugeskrift for Læger nr. 42

ufl42

Mælkesukkerproblemer kan nu nemt bestemmes i en blodprøve

Mangelfuld optagelse af mælkesukker kan give luft i maven, mavesmerter og diare. Tidligere var det besværligt at teste personer for, om de havde problemer med mælkesukkeroptagelsen, men nu har forskerne fundet det gen, der bevirker, at man får disse problemer, og derfor kan det gøres ved en simpel blodprøve.

»  Diagnosticering af laktoseintolerans hos voksne
»  Leder: Laktoseintolerans - mælk og molekylærbiologi
»  Laktoseintolerans

 

2008-09-11: Speciale Studerende i Kræftforskning

Hos Molekylær Diagnostisk Laboratorium, Klinisk Biokemisk Afdeling, Skejby Sygehus arbejder vi med molekylær karakteristik af blære-, prostata- og tarmkræft. Målet med forskningen er at opnå en molekylær klassifikation af sygdommene for dermed at kunne give en mere optimal behandling af patienterne. Desuden er målet at opnå en større forståelse af sygdommenes molekylære forhold i aktive pathways og i relation til sygdomsforløb og behandlingsrespons.
Projektet vil tage udgangspunkt i molekylære forandringer i tumorvæv som har en klinisk relevans. Det kan f.eks. være microRNA eller mRNA transkript profiler som er relateret til udvikling af metastaser eller respons på kemoterapi. Projektet vil bl.a. involvere immunhistokemiske analyser, overudtryks- eller knockdown analyser såvel som funktionelle assays til måling af f.eks. apoptose, proliferation og invasionspotentiale efter in vitro overudtryk eller knockdown af relevante molekyler. Relevante molekyler vil blive udvalgt til klinisk afprøvning.
Er du interesseret i at lave speciale inden for kræftforskning og indgå i et spændende forskermiljø så kontakt Karin Demtröder på tlf. 8949-5119 eller Professor Torben Ørntoft på tlf. 8949-5100.
Du kan læse mere om vores aktuelle forskning på www.mdl.dk

Du kan læse mere her Her

2007-09-04: Gentest forudsiger skæbnen for blærekræftpatienter
 
Forskere fra Skejby Sygehus har udviklet en genchip, som kan afsløre, hvor slemt blærekræftpatienter er ramt af deres sygdom. Det viser en ny undersøgelse, hvor fire lande udover Danmark har deltaget. Et stort skridt på vejen til, at chippen kan blive en naturlig del af hospitalsgangen og hjælpe til, at blærekræftpatienter får den bedste og mest nænsomme behandling.
 
Læs den fulde artikel her  

2007-03-19: Updated Request Form

The request form for diagnostic genetical analysises has been updated to version 8, please download from www.mdl.dk/rekvisition.pdf.

2007-03-12: MDL 10-year anniversary

On May, 1st 1997 MDL was officially founded. The 10-year anniversary will be celebrated on April, 27th.

2007-02-26: Updated Request Form

The request form for diagnostic genetical analysises has been updated, please download from www.mdl.dk/rekvisition.pdf.

2007-02-21: Vacant positions

MDL has three open postdoc positions (3-years) in Clinical Molecular Cancer Research. Applicants will be evaluated by a review committee at Aarhus University, The Faculty of Health Sciences.

Read job announcements (Danish)

Application deadline: March 19th, 2007

2006-12-04: Cells get old fighting cancer

Photo: Kræftens Bekæmpelse
Photo: Kræftens Bekæmpelse

International cooperation, led by the known researchers and spouses Jirina Bartkova and Jiri Bartek at The Danish Cancer Society, Copenhagen, and with Danish scientists from The Danish Cancer Society, MDL and Rigshospitalet resulted in another publication in the recognized journal Nature:

Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Orntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG.
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 2006 Nov 30;444(7119):633-7. PubMed

Read more (in Danish) at the The Danish Cancer Society website.

2006-09-27: Vacant position for molecular biologist

MDL seeks a molecular biologist full-time (37 h/week). Application deadline: 16th October 2006. Read more (Danish)...

See job announcement (in Danish)

2006-07-27: New research results within colorectal cancer therapy

MDL contributed to results published in Nature Genetics, that inflict the therapy of colorectal cancer with HDAC inhibitors. In the future, an individual test for a certain mutation can decide if HDAC-inhibition therapy is useful or not.

Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H, Boix-Chornet M, Caballero R, Alaminos M, Setien F, Paz MF, Herranz M, Palacios J, Arango D, Orntoft TF, Aaltonen LA, Schwartz S, Esteller M. A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nat Genet. 2006 May;38(5):566-9. Epub 2006 Apr 16. PubMed

Read this in Danish

2006-06-28: MDL seeks graduate student

The prostate cancer group at MDL seeks a graduate student (molecular biology) for a master thesis project from September, 1st 2006:
"Characterization of a new tumour suppressor gene candidate in prostate cancer by overexpression, siRNA knock-down and microarray analysis"

Further information

2006-05-17: MDL offers a new genetic analysis

A mutation screen for adult–type hypolactasia (LCT -13910C>T) is offered in MDL's panel of diagnostic services. Please refer to the Dep. of Clinical Biochemistry for further information. A new requisition form can be downloaded.

2006-02-09: MDL participates in ”The MicroRNA Research
Consortium – Towards novel molecular targets for LNA-based
cancer therapy”

The Danish High Technology Fund under the Ministry of Science has granted 10 million Danish Kroner for the development of diagnostic techniques to measure microRNA. The consortium consists of The University of Copenhagen, Aarhus University Hospital (MDL), Bioneer, Exiqon, Visiopharm and Novo Nordisk including Steno Diabetes Center. Together with the investements of the participants the budget will be 32 million Danish Kroner over three years. A kick-off meeting will be held soon. Read more (in Danish)...

2006-01-24: MDL comments on breakthrough in prostate cancer research
American researchers have published results in Science that show chromosomal changes in 80% of prostate cancer patients, a fusion of the TMPRSS2 and ETS transcription factor genes. These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer.

Niels Tørring, Ph.d. and leader of MDL's prostate cancer research group comments on the website of the Danish Cancer Society (in Danish).

2005-11-11: MDL passes German External Quality Assessment scheme with full marks

MDL participated in an External Quality Assessment (EQA) program for molecular diagnostics of HNPCC 2005 in Bonn and München, Germany. Participants included 12 German members of "Berufsverband Deutscher Humangenetiker e.V." and HNPCC centres supported by the German Cancer Aid as well as four laboratories from abroad. Nine laboratories including MDL achieved the maximum 18 points for mutational analysis by sequencing, MLPA and DHPLC, interpretation and written report to the counselling physician evaluating the results and diagnostics possibilities/recommendation for family members of the screened patient.

2005-08-22: GEO data available

Download our microarray raw data directly for selected publications using the GENE EXPRESSION OMNIBUS (GEO) database at NCBI.

See under supplementary data.

2005-06-21: MDL in "Augustus"

MDL's research is covered by an article in the latest issue of Århus University's alumne magazine "Augustus" (page 20, in Danish).

2005-05-23: Prof. T. Ørntoft receives award
The "Consul Ernst Carlsen Honorary Award" of 60.000 Danish Kroner for excellent cancer research and humanitarian achievements, carried out by prof. Torben Ørntoft and his research group at MDL, was given to prof. Torben Ørntoft at monday. The award is granted by a committee consisting of representatives from Danish Universities.
Read more in Danish...

2005-04-14: Research results from MDL on "Nature" cover
Danish cancer researchers from The Danish Cancer Society, MDL and researchers from Institutes in Norway and the Czech Republic have published the articel: "DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis" in the recognized scientific journal "Nature" today.

See also comments in 'News and Views' in the same issue: "Aborting the birth of cancer".

Read more (in Danish) from Aarhus University Hospital, The Danish Cancer Society and see this news on the Danish National TV.

2005-04-04: Request form for genetic analysis
To order genetic analysis service, please use this request form (in Danish).
2005-03-01: Center for Molecular Cancer Research
CMCC, a John and Birthe Meyer Cancer Center, will be officially opened at March, 3rd at the Science Park at Skejby Hospital.

2005-02-01: NormFinder software
A new version of NormFinder for R and version 0.953 of the MS Excel add-in are now available for direct download.

2004-11-02: Job announcements
MDL has vacant positions in Clinical Molecular Cancer Research as researcher or group leader.
Application deadline is by November, 19th, 2004.
2004-08-23: NormFinder software
NormFinder - a new MS Excel add-in for normalization of real-time quantitative RT-PCR data developed by MDL.
2004-08-10: Symposium announcement
The Third Symposium on Array Technology in Research and Diagnostics will be held from October, 29th to 30th, 2004 at the Aarhus University Hospital, Skejby.
2004-06-22: MDL receives major funding
MDL has received a major donation of The John and Birthe Meyer Foundation of 19.8 million Danish Kroner (about 2,6 mill. Euro) to strengthen and enhance its research in bladder, colon and prostate cancer. A new Center for Molecular Clinical Cancer Research will be founded at Aarhus University Hospital at Skejby in January 2005. MDL will cooperate with clinical and surgical departments from different hospitals as well as research laboratories at Aarhus University to gather and investigate numerous tumor samples. Read this in Danish

 


Updated:8 January, 2013

 
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MOMA, Aarhus University Hospital, Brendstrupgårdsvej 100, 8200 Aarhus N, Denmark     
Phone +45 7845 5310| Fax +45 8678 2108 | email: contact@mdl.dk | webmaster: webmaster@mdl.dk