2009-07-06: Vacant positions postdocs/assistant professor

Several academic positions (full-time) as researcher in molecular clinical cancer research are available at MDL. Application deadline September, 6th 2009.

Read full job announcement.

Project descriptions for bladder and prostate cancer positions.

Project descriptions for colon cancer positions.

2009-06-25: Vacant position administrator

MDL offers a vacant position as an all-round research administrator, application deadline August 31, 2009.

Read more (Danish).

2009-06-24: MDL is granted a 19.5 million Danish Kroner appropriation

We gladly announce that CMCC, The John and Birthe Meyer Cancer Center for Molecular and Clinical Cancer Research under the Dept. of Molecular Medicine, has received a major grant from the Meyer Foundation which assures continuation of our high-standard cancer research for the next five years.

CMCC's research focuses on molecular classification of cancer patients at high risk of disease and identification of patients with the most agressive tumours. To achieve this, the newest molecular technologies and extensive biobanks are applied.

Read more (Danish).

2009-06-15: NormFinder software

We are happy to note a frequent use of our NormFinder software and a high number of inquiries. Therefore, we have updated the NormFinder documentation (v19) and created a sample data set, which better illustrates the use of the NormFinder software.

We hope to have answered frequently asked questions about group identifiers, data sheet organisation and evaluation of top ranked normalisation genes.

If you need more help, please use the information on the NormFinder page.

2009-05-31: MDL research on "Cancer Research" cover

Associated professor Lars Dyrskjøt, who recently won a prize being "The most publishing researcher aged under 40 at Skejby Hospital", led the work on miRNAs in bladder cancer resulting in this publication:

Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro. Dyrskjøt L, Ostenfeld MS, Bramsen JB, Silahtaroglu AN, Lamy P, Ramanathan R, Fristrup N, Jensen JL, Andersen CL, Zieger K, Kauppinen S, Ulhøi BP, Kjems J, Borre M, Orntoft TF. Cancer Res. 2009 Jun 1;69(11):4851-60.

Read more (in Danish).

See coverage by regional TV (Danish).

2009-01-27: MOMA opening

The official opening of the novel Department of Molecular Medicine (MOMA) at Aarhus University Hospital Skejby takes place at March, 11th 2009.

MDL will be hosting a two-day symposium "Molecular Oncology" mainly aimed at PhD students and Postdocs in molecular cancer research to celebrate the inauguration of MOMA at March 12-13th, 2009.

invitation

program

2008-11-19: MDL is moving

In december 2008 MDL will move to new locations at the Science Center Skejby (former residence of the newspaper Århus Stifstidende) nearby and belong to the new Department of Molecular Medicine (MOMA) at the Århus University Hospital Skejby.
The official opening will take place in march 2009.

MDL is going to enjoy spacious and modern facilities, which make room for state-of-the-art equipment and provide stimulating working surroundings for the staff.

New phone numbers from 16-12-2008:

Laboratory +45 8949 9430
Secretary +45 8949 9410

Read more about MOMA (Dept. of Molecular Medicine) in Danish

2008-10-14: MDL's gentest for laktoseintolerans omtalt i Ugeskrift for Læger nr. 42

Mælkesukkerproblemer kan nu nemt bestemmes i en blodprøve

Mangelfuld optagelse af mælkesukker kan give luft i maven, mavesmerter og diare. Tidligere var det besværligt at teste personer for, om de havde problemer med mælkesukkeroptagelsen, men nu har forskerne fundet det gen, der bevirker, at man får disse problemer, og derfor kan det gøres ved en simpel blodprøve.

»  Diagnosticering af laktoseintolerans hos voksne
»  Leder: Laktoseintolerans - mælk og molekylærbiologi
»  Laktoseintolerans

Download som pdf.

2008-09-11: Speciale Studerende i Kræftforskning

Hos Molekylær Diagnostisk Laboratorium, Klinisk Biokemisk Afdeling, Skejby Sygehus arbejder vi med molekylær karakteristik af blære-, prostata- og tarmkræft. Målet med forskningen er at opnå en molekylær klassifikation af sygdommene for dermed at kunne give en mere optimal behandling af patienterne. Desuden er målet at opnå en større forståelse af sygdommenes molekylære forhold i aktive pathways og i relation til sygdomsforløb og behandlingsrespons.
Projektet vil tage udgangspunkt i molekylære forandringer i tumorvæv som har en klinisk relevans. Det kan f.eks. være microRNA eller mRNA transkript profiler som er relateret til udvikling af metastaser eller respons på kemoterapi. Projektet vil bl.a. involvere immunhistokemiske analyser, overudtryks- eller knockdown analyser såvel som funktionelle assays til måling af f.eks. apoptose, proliferation og invasionspotentiale efter in vitro overudtryk eller knockdown af relevante molekyler. Relevante molekyler vil blive udvalgt til klinisk afprøvning.
Er du interesseret i at lave speciale inden for kræftforskning og indgå i et spændende forskermiljø så kontakt Karin Demtröder på tlf. 8949-5119 eller Professor Torben Ørntoft på tlf. 8949-5100.
Du kan læse mere om vores aktuelle forskning på www.mdl.dk

Du kan læse mere her Her

2007-03-19: Updated Request Form

The request form for diagnostic genetical analysises has been updated to version 8, please download from www.mdl.dk/rekvisition.pdf.

2007-03-12: MDL 10-year anniversary

On May, 1st 1997 MDL was officially founded. The 10-year anniversary will be celebrated on April, 27th.

2007-02-26: Updated Request Form

The request form for diagnostic genetical analysises has been updated, please download from www.mdl.dk/rekvisition.pdf.

2007-02-21: Vacant positions

MDL has three open postdoc positions (3-years) in Clinical Molecular Cancer Research. Applicants will be evaluated by a review committee at Aarhus University, The Faculty of Health Sciences.

Read job announcements (Danish)

Application deadline: March 19th, 2007

2006-12-04: Cells get old fighting cancer

Photo: Kræftens Bekæmpelse

International cooperation, led by the known researchers and spouses Jirina Bartkova and Jiri Bartek at The Danish Cancer Society, Copenhagen, and with Danish scientists from The Danish Cancer Society, MDL and Rigshospitalet resulted in another publication in the recognized journal Nature:

Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Orntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG.
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 2006 Nov 30;444(7119):633-7. PubMed

Read more (in Danish) at the The Danish Cancer Society website.

2006-09-27: Vacant position for molecular biologist

MDL seeks a molecular biologist full-time (37 h/week). Application deadline: 16th October 2006. Read more (Danish)...

See job announcement (in Danish)

2006-07-27: New research results within colorectal cancer therapy

MDL contributed to results published in Nature Genetics, that inflict the therapy of colorectal cancer with HDAC inhibitors. In the future, an individual test for a certain mutation can decide if HDAC-inhibition therapy is useful or not.

Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H, Boix-Chornet M, Caballero R, Alaminos M, Setien F, Paz MF, Herranz M, Palacios J, Arango D, Orntoft TF, Aaltonen LA, Schwartz S, Esteller M. A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nat Genet. 2006 May;38(5):566-9. Epub 2006 Apr 16. PubMed

Read this in Danish

2006-06-28: MDL seeks graduate student

The prostate cancer group at MDL seeks a graduate student (molecular biology) for a master thesis project from September, 1st 2006:
"Characterization of a new tumour suppressor gene candidate in prostate cancer by overexpression, siRNA knock-down and microarray analysis"

Further information

2006-05-17: MDL offers a new genetic analysis

A mutation screen for adult–type hypolactasia (LCT -13910C>T) is offered in MDL's panel of diagnostic services. Please refer to the Dep. of Clinical Biochemistry for further information. A new requisition form can be downloaded.

2006-02-09: MDL participates in ”The MicroRNA Research
Consortium – Towards novel molecular targets for LNA-based
cancer therapy”
The Danish High Technology Fund under the Ministry of Science has granted 10 million Danish Kroner for the development of diagnostic techniques to measure microRNA. The consortium consists of The University of Copenhagen, Aarhus University Hospital (MDL), Bioneer, Exiqon, Visiopharm and Novo Nordisk including Steno Diabetes Center. Together with the investements of the participants the budget will be 32 million Danish Kroner over three years. A kick-off meeting will be held soon. Read more (in Danish)...

2006-01-24: MDL comments on breakthrough in prostate cancer research
American researchers have published results in Science that show chromosomal changes in 80% of prostate cancer patients, a fusion of the TMPRSS2 and ETS transcription factor genes. These results have implications in the development of carcinomas and the molecular diagnosis and treatment of prostate cancer.

Niels Tørring, Ph.d. and leader of MDL's prostate cancer research group comments on the website of the Danish Cancer Society (in Danish).

2005-11-11: MDL passes German External Quality Assessment scheme with full marks

MDL participated in an External Quality Assessment (EQA) program for molecular diagnostics of HNPCC 2005 in Bonn and München, Germany. Participants included 12 German members of "Berufsverband Deutscher Humangenetiker e.V." and HNPCC centres supported by the German Cancer Aid as well as four laboratories from abroad. Nine laboratories including MDL achieved the maximum 18 points for mutational analysis by sequencing, MLPA and DHPLC, interpretation and written report to the counselling physician evaluating the results and diagnostics possibilities/recommendation for family members of the screened patient.

2005-08-22: GEO data available

Download our microarray raw data directly for selected publications using the GENE EXPRESSION OMNIBUS (GEO) database at NCBI.

See under supplementary data.

2005-06-21: MDL in "Augustus"

MDL's research is covered by an article in the latest issue of Århus University's alumne magazine "Augustus" (page 20, in Danish).

2005-05-23: Prof. T. Ørntoft receives award
The "Consul Ernst Carlsen Honorary Award" of 60.000 Danish Kroner for excellent cancer research and humanitarian achievements, carried out by prof. Torben Ørntoft and his research group at MDL, was given to prof. Torben Ørntoft at monday. The award is granted by a committee consisting of representatives from Danish Universities.
Read more in Danish...

2005-04-14: Research results from MDL on "Nature" cover
Danish cancer researchers from The Danish Cancer Society, MDL and researchers from Institutes in Norway and the Czech Republic have published the articel: "DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis" in the recognized scientific journal "Nature" today.

See also comments in 'News and Views' in the same issue: "Aborting the birth of cancer".

Read more (in Danish) from Aarhus University Hospital, The Danish Cancer Society and see this news on the Danish National TV.

2005-02-01: NormFinder software
A new version of NormFinder for R and version 0.953 of the MS Excel add-in are now available for direct download.