Molecular Diagnostic Laboratory, Aarhus

2007

According to JCR Science Edition 2007, the total impact factor of these 23 publications is 96 (2 journals not present), with 19 publications with an impact factor above 2.5.

Adolf K, Wagner L, Bergh A, Stattin P, Ottosen P, Borre M, Birkenkamp-Demtröder K, Orntoft TF, Torring N.
Secretagogin is a new neuroendocrine marker in the human prostate.
The Prostate. 2007 Apr 1;67(5):472-84. Epub 2007 Feb 6. PubMed

Als AB, Dyrskjøt L, von der Maase H, Koed K, Mansilla F, Toldbod HE, Jensen JL, Ulhøi BP, Sengeløv L, Jensen KM, Ørntoft TF.
Emmprin and Survivin Predict Response and Survival following Cisplatin-Containing Chemotherapy in Patients with Advanced Bladder Cancer.
Clin Cancer Res. 2007 Aug 1;13(15):4407-14 PubMed

Andersen CL, Schepeler T, Thorsen K, Birkenkamp-Demtröder K, Mansilla F, Aaltonen LA, Laurberg S, Ørntoft TF.
Clusterin expression in normal mucosa and colorectal cancer.
Mol Cell Proteomics. 2007 Jun;6(6):1039-48. Epub 2007 Feb 23. PubMed

Bergholdt R, Karlsen AE, Hagedorn PH, Aalund M, Nielsen JH, Kruhoffer M, Orntoft T, Wang H, Wollheim CB, Nerup J, Pociot F.
Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets.
Genes Immun. 2007 Apr;8(3):232-8. Epub 2007 Mar 1. PubMed

Birkenkamp-Demtroder, K., Mansilla, F., Sørensen F.B., Kruhoeffer, M., Christensen, L.L., Aaltonen, L.A., Verspaget, H.W. and Ørntoft T.F.
Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro.
Mol Oncol. 2007 Sep;1(2):181-95. Epub 2007 Jun 3. PubMed

Daugaard M, Kirkegaard-Sorensen T, Ostenfeld MS, Aaboe M, Hoyer-Hansen M, Orntoft TF, Rohde M, Jaattela M.
Lens Epithelium-Derived Growth Factor Is an Hsp70-2 Regulated Guardian of Lysosomal Stability in Human Cancer.
Cancer Res. 2007 Mar 15;67(6):2559-2567. PubMed

De Martino I, Visone R, Palmieri D, Cappabianca P, Chieffi P, Forzati F, Barbieri A, Kruhoffer M, Lombardi G, Fusco A, Fedele M.
The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas.
Endocr Relat Cancer. 2007 Sep;14(3):875-886. PubMed

Dyrskjot L, Zieger K, Orntoft TF.
Recent advances in high-throughput molecular marker identification for superficial and invasive bladder cancers.
Front Biosci. 2007 Jan 1;12:2063-73. Review. PubMed

Dyrskjot L, Zieger K, Real FX, Malats N, Carrato A, Hurst C, Kotwal S, Knowles M, Malmstrom PU, de la Torre M, Wester K, Allory Y, Vordos D, Caillault A, Radvanyi F, Hein AM, Jensen JL, Jensen KM, Marcussen N, Orntoft TF.
Gene expression signatures predict outcome in non-muscle-invasive bladder carcinoma: a multicenter validation study.
Clin Cancer Res. 2007 Jun 15;13(12):3545-51. PubMed

Ehlers N, Hjortdal J, Nielsen K, Thiel HJ, Orntoft T.
Phenotypic variability in Meesmann's dystrophy: clinical review of the literature and presentation of a family genetically identical to the original family.
Acta Ophthalmol Scand. 2007 Nov 6. PubMed

Kruhoffer M, Dyrskjot L, Voss T, Lindberg RL, Wyrich R, Thykjaer T, Orntoft TF.
Isolation of Microarray-Grade Total RNA, MicroRNA, and DNA from a Single PAXgene Blood RNA Tube.
J Mol Diagn. 2007 [Epub ahead of print] PubMed

Lamy P, Andersen CL, Dyrskjot L, Torring N, Wiuf C.
A Hidden Markov Model to estimate population mixture and allelic copy-numbers in cancers using Affymetrix SNP arrays.
BMC Bioinformatics. 2007 Nov 9;8(1):434. PubMed

Larsen PF, Nielsen EE, Williams TD, Hemmer-Hansen J, Chipman JK, Kruhoffer M, Gronkjaer P, George SG, Dyrskjot L, Loeschcke V.
Adaptive differences in gene expression in European flounder (Platichthys flesus).
Mol Ecol. 2007 Oct 8; [Epub ahead of print] PubMed

Mansilla, F., Wang, S., da Costa, K.A., Kruhøffer, M., Lewin, T.M., Ørntoft,T.F., Coleman, R.A. and Birkenkamp-Demtroder, K. (2007) From microarray analysis to protein function: Overexpression of LPCAT1 in colorectal cancer.
Journal of Biotechnology, Volume 131, Issue 2, Supplement 1

Mansilla F, Birkenkamp-Demtroder K, Kruhoffer M, Sorensen FB, Andersen CL, Laiho P, Aaltonen LA, Verspaget HW, Orntoft TF. Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups. Br J Cancer. 2007 96(12):1896-1903. Epub 2007 May 22. PubMed

Niemelä AM, Hynninen P, Mecklin JP, Kuopio T, Kokko A, Aaltonen L, Parkkila AK, Pastorekova S, Pastorek J, Waheed A, Sly WS, Orntoft TF, Kruhøffer M, Haapasalo H, Parkkila S, Kivelä AJ.
Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer.
Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1760-6. PubMed

Pirot P, Naamane N, Libert F, Magnusson NE, Orntoft TF, Cardozo AK, Eizirik DL. Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs. Diabetologia. 2007 May;50(5):1006-14. Epub 2007 Mar 1. PubMed

Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Makinen MJ, Birkenkamp-Demtroder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA. No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia.
Endocr Relat Cancer. 2007 Sep;14(3):901-6. PubMed

Salvig JD, Winding TN, Henriksen TB, Torring N, Pedersen OB, Uldbjerg N.
PAPP-A and fetal growth from week 12 to week 20.
Ultrasound Obstet Gynecol. 2007 Sep 21;30(4):460 PubMed

Schepeler T, Mansilla F, Christensen LL, Orntoft TF, Andersen CL.
Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling.
J Mol Signal. 2007 Jul 16;2:6. PubMed

Sorensen KD, Borre M, Orntoft TF, Dyrskjot L, Torring N.
Chromosomal deletion, promoter hypermethylation and downregulation of FYN in prostate cancer. Int J Cancer. 2007 Oct 17; [Epub ahead of print] PubMed

Torring N, Borre M, Sorensen KD, Andersen CL, Wiuf C, Orntoft TF.
Genome-wide analysis of allelic imbalance in prostate cancer using the Affymetrix 50K SNP mapping array. Br J Cancer. 2007 Feb 12;96(3):499-506. Epub 2007 Jan 23. PubMed

Visconti R, Federico A, Coppola V, Pentimalli F, Berlingieri MT, Pallante P, Kruhoffer M, Orntoft TF, Fusco A.
Transcriptional profile of Ki-Ras-induced transformation of thyroid cells.
Cancer Invest. 2007 Jun;25(4):256-66. PubMed

2006

According to JCR Science Edition 2005, the total impact factor of these 21 publications is 140, with 17 publications with an impact factor above 2.5.

Aaboe M, Birkenkamp-Demtroder K, Wiuf C, Sørensen FB, Thykjaer T, Sauter G, Møller-Ernst Jensen K, Dyrskjøt L, Ørntoft TF. SOX4 expression in bladder carcinoma: clinical aspects and in vitro functional characterization. Cancer Research. 2006. Apr 1;66(7):3434-42. PubMed Suppl Data

Andersen CL, Wiuf C, Kruhoffer M, Korsgaard M, Laurberg, S and Orntoft TF. Frequent occurrence of uniparental disomy in colorectal cancer. Carcinogenesis. 2007 Jan;28(1):38-48. Epub 2006 Jun 13. PubMed

Andersen JB, Aaboe M, Borden EC, Goloubeva OG, Hassel BA, Ørntoft TF. Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer. Br J Cancer. 2006 May 22;94(10):1465-71. PubMed

Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Orntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 2006 Nov 30;444(7119):633-7. PubMed

Colombo M, Kruhoeffer M, Gregersen S, Agger A, Jeppesen P, Oerntoft T, Hermansen K. Energy restriction prevents the development of type 2 diabetes in Zucker diabetic fatty rats: coordinated patterns of gene expression for energy metabolism in insulin-sensitive tissues and pancreatic islets determined by oligonucleotide microarray analysis. Metabolism. 2006 Jan;55(1):43-52. PubMed Suppl Data

Dahl C, Saito H, Kruhoffer M, Schiotz PO . Identification of tryptase- and chymase-related gene clusters in human mast cells using microarrays. Allergy. 2006 Mar;61(3):276-80. PubMed

Ebbesen LS, Olesen SH, Kruhoffer M, Ingerslev J, Orntoft TF. Folate deficiency induced hyperhomocysteinemia changes the expression of thrombosis-related genes. Blood Coagul Fibrinolysis. 2006 Jun;17(4):293-301. PubMed

Frohlich C, Albrechtsen R, Dyrskjot L, Rudkjaer L, Orntoft TF, Wewer UM. Molecular Profiling of ADAM12 in Human Bladder Cancer. Clin Cancer Res. 2006 Dec 15;12(24):7359-7368. PubMed

Gaustadnes M, Orntoft TF, Jensen JL, Torring N. Validation of the use of DNA pools and primer extension in association studies of sporadic colorectal cancer for selection of candidate SNPs. Hum Mutat. 2006 Feb;27(2):187-94. PubMed

Holten-Andersen MN, Brunner N, Nielsen HJ, Christensen IJ, Sorensen NM, Rasmussen AS, Primdahl H, Orntoft T. Levels of tissue inhibitor of metalloproteinases 1 in plasma and urine from patients with bladder cancer. Int J Biol Markers. 2006 Jan-Mar;21(1):6-11. PubMed

Kristensen TN , Sorensen P, Pedersen KS , Kruhoffer M, Loeschcke V. Inbreeding by environment interactions affect gene expression in Drosophila melanogaster. Genetics. 2006 Jul;173(3):1329-36. Epub 2006 Apr 19. PubMed

Lamy P, Andersen CL, Dyrskjot L, Torring N, Orntoft T, Wiuf C. Are microRNAs located in genomic regions associated with cancer? Br J Cancer. 2006 Nov 20;95(10):1415-8. Epub 2006 Sep 26. PubMed

Marcheco-Teruel B, Flint TJ, Wikman FP, Torralbas M, Gonzalez L, Blanco L, Tan Q, Ewald H, Orntoft T, Kruse TA, Borglum AD, Mors O. A genome-wide linkage search for bipolar disorder susceptibility loci in a large and complex pedigree from the eastern part of Cuba . Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141(8):833-43. PubMed

Memon AA, Sorensen BS, Meldgaard P, Fokdal L, Thykjaer T, Nexo E. The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients. Br J Cancer. 2006 Jun 5;94(11):1703-9. PubMed

Nielsen K, Vorum H, Fagerholm P, Birkenkamp-Demtroder K, Honore B, Ehlers N, Orntoft TF. Proteome Profiling of Corneal Epithelium and Identification of Marker Proteins for Keratoconus, a pilot study. Exp Eye Res. 2006 Feb;82(2):201-9. Epub 2005 Aug 3. PubMed

Nielsen MM, Sorensen JG, Kruhoffer M, Justesen J, Loeschcke V. Phototransduction genes are up-regulated in a global gene expression study of Drosophila melanogaster selected for heat resistance.
Cell Stress Chaperones. 2006 Winter;11(4):325-33. PubMed

Orntoft TF, Zieger K, Dyrskjot L. Recent developments in molecular profiling of bladder cancer. Curr Opin Urol. 2006 Sep;16(5):377-81. Review. PubMed

Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H, Boix-Chornet M, Caballero R, Alaminos M, Setien F, Paz MF, Herranz M, Palacios J, Arango D, Orntoft TF, Aaltonen LA, Schwartz S , Esteller M. A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nat Genet. 2006 May;38(5):566-9. Epub 2006 Apr 16. PubMed

Tort F, Bartkova J, Sehested M, Orntoft T, Lukas J, Bartek J. Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis.
Cancer Res. 2006 Nov 1;66(21):10258-63. PubMed

Vanharanta S, Pollard PJ, Lehtonen HJ, Laiho P, Sjoberg J, Leminen A, Aittomaki K, Arola J, Kruhoffer M, Orntoft TF, Tomlinson IP, Kiuru M, Arango D, Aaltonen LA: Distinct expression profile in fumarate-hydratase-deficient uterine fibroids. Hum Mol Genet. 2006 Jan 1;15(1):97-103. Epub 2005 Nov 30. PubMed

Vestergaard EM, Borre M, Poulsen SS, Nexo E, Torring N. Plasma levels of trefoil factors are increased in patients with advanced prostate cancer. Clinical Cancer Research. 2006 Feb 1;12( 3 Pt 1):807-12. PubMed

Ylisaukko-Oja SK, Cybulski C, Lehtonen R, Kiuru M, Matyjasik J, Szymanska A, Szymanska-Pasternak J, Dyrskjot L, Butzow R, Orntoft TF, Launonen V, Lubinski J, Aaltonen LA.
Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma.
Eur J Hum Genet. 2006 Jul;14(7):880-3. Epub 2006 Apr 26. PubMed

According to JCR Science Edition 2005, the total impact factor of these 26 publications is 156, with 20 publications with an impact factor above 2.5.

Aaboe M, Marcussen N, Jensen KM, Thykjaer T, Dyrskjot L, Orntoft TF. Gene expression profiling of noninvasive primary urothelial tumours using microarrays. Br J Cancer. 2005. Nov 14;93(10):1182-90. PubMed Suppl Data

Andersen C.L., Jacobsen E., Gruszka A., Matutes E., Catovsky D., Koch J. : Recurrent genomic imbalances in B-cell splenic marginal zone lymphoma revealed by comparative genomic hybridization. Cancer genetics and Cytogenetics. 2005; 156(2):122-128. PubMed

Bartkova,J., Horejsi,Z., Koed,K., Kramer,A., Tort,F., Zieger,K., Guldberg,P., Sehested,M., Nesland,J.M., Lukas,C., Orntoft,T., Lukas,J., Bartek,J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature. 434(7035): 864-870. 2005. PubMed

Birkenkamp-Demtröder, K., Olesen, S.H., Sørensen,F.B., Laurberg, S., Laiho, P., Aaltonen, L.A., and Ørntoft, T.F. Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. Gut. 2005. Mar;54(3):374-84 PubMed

Birkenkamp-Demtröder K, Wagner L, Sørensen FB, Astrup LB, Gartner W, Scherübl H, Heine B, Christiansen P, Ørntoft TF. Secretagogin is a novel marker for neuroendocrine differentiation. Neuroendocrinology. 2005;82(2):121-38. Epub 2006 Jan 30 PubMed

Colombo M, Gregersen S, Kruhoeffer M, Agger A, Xiao J, Jeppesen PB, Orntoft T, Ploug T, Galbo H, Hermansen K. Prevention of hyperglycemia in Zucker diabetic fatty rats by exercise training: effects on gene expression in insulin-sensitive tissues determined by high-density oligonucleotide microarray analysis, Metabolism, 54 (12): 1571-81, 2005. PubMed Suppl Data

Dyrskjøt L, Zieger K, Kruhøffer M, Thykjaer T, Jensen JL, Primdahl H, Aziz N, Marcussen N, Møller K and Ørntoft TF. A molecular signature in superficial bladder carcinoma predicts clinical outcome. Clinical Cancer Research. 2005. June 1, 11 (11): PubMed Suppl Data

Enver,T., Soneji,S., Joshi,C., Brown,J., Iborra,F., Orntoft,T., Thykjaer,T., Maltby,E., Smith,K., Abu,D.R., Jones,M., Matin,M., Gokhale,P., Draper,J. and Andrews,P.W. Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells. Hum Mol Genet. 2005 Nov 1;14(21):3129-40. Epub 2005 Sep 13. PubMed

Eschrich,S., Yang,I., Bloom,G., Kwong,K.Y., Boulware,D., Cantor,A., Coppola,D., Kruhoffer,M., Aaltonen,L., Orntoft,T.F., Quackenbush,J., Yeatman,T.J. Molecular staging for survival prediction of colorectal cancer patients. J Clin.Oncol.. 23(15): 3526-3535. 2005. PubMed

Ewald,H., Wikman,F.P., Teruel,B.M., Buttenschon,H.N., Torralba,M., Als,T.D., El,Daoud A., Flint,T.J., Jorgensen,T.H., Blanco,L., Kruse,T.A., Orntoft,T.F., Mors,O. A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder. Am.J Med Genet.B Neuropsychiatr.Genet.. 133(1): 25-30. 2005. PubMed

Harnacke K, Kruhoffer M, Orntoft TF, Hass R. Down-modulation of poly(ADP-ribose) polymerase-1 (PARP-1) in human TUR leukemia cells restores transcriptional responsiveness for differentiation and cell cycle arrest. Eur J Cell Biol. 2005 Nov;84(11):885-96. PubMed

Kalbe,L., Leunda,A., Sparre,T., Meulemans,C., Ahn,M.T., Orntoft,T., Kruhoffer,M., Reusens,B., Nerup,J., Remacle,C. Nutritional regulation of proteases involved in fetal rat insulin secretion and islet cell proliferation. Br.J Nutr.. 93(3): 309-316. 2005. PubMed

Koed, K., Wiuf,C., Christensen, L.L., Wikman, F., Zieger, K., Møller, K., von der Maase, H., Ørntoft, T.F. High-density single nucleotide polymorphism array defines novel stage and location-dependent allelic imbalances in human bladder tumors. Cancer Research. 2005. 65 (1):34-45. PubMed Suppl data

Kristensen TN, Sørensen P, Kruhøffer M, Pedersen KS, and Loeschcke V. Genome wide analysis on inbreeding effects on gene expression in Drosophila melanogaster. Genetics. 2005 Sep;171(1):157-67. Epub 2005 Jun 8. PubMed

Kruhøffer, M., Jensen J.L., Laiho, P., Dyrskjøt, L., Salovaara, R., Arango, D., Birkenkamp-Demtroder, K., Christensen, L.L., Sørensen, F.B., Buhl, L., Mecklin J-P., Järvinen, H., Thykjaer, T., Wikman, F.P., Bech-Knudsen, F., Juhola, M., Nupponen, N.N., Lauerberg, S., Andersen, C.L., Aaltonen, L.A. and Ørntoft, T.F. (2005) Gene expression signatures for colorectal cancer microsatellite status and HNPCC. British Journal of Cancer. 2005 Jun 20;92(12):2240-8. PubMed

Lund,L., Moller Ernst-Jensen,K., Torring,N. and Erik,N.J. Impact of finasteride treatment on perioperative bleeding before transurethral resection of the prostate: a prospective randomized study, Scand.J Urol.Nephrol., 39: 160-162, 2005. PubMed

Magnusson NE, Cardozo AK, Kruhoffer M, Eizirik DL, Orntoft TF, Jensen JL. Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis. BMC Bioinformatics. 2005 Dec 29;6(1):311 [Epub ahead of print] PubMed


	Molecular Diagnostic Laboratory
	Department of Molecular Medicine, Aarhus University Hospital Skejby
	2012 \| 2011 \| 2010 \| 2009 \| 2008\| 2005 -2007 \| 1996- 2004 \| Supplementary data \| NormFinder \|Graduations
		2007 According to JCR Science Edition 2007, the total impact factor of these 23 publications is 96 (2 journals not present), with 19 publications with an impact factor above 2.5. Adolf K, Wagner L, Bergh A, Stattin P, Ottosen P, Borre M, Birkenkamp-Demtröder K, Orntoft TF, Torring N. Secretagogin is a new neuroendocrine marker in the human prostate. The Prostate. 2007 Apr 1;67(5):472-84. Epub 2007 Feb 6. PubMed Als AB, Dyrskjøt L, von der Maase H, Koed K, Mansilla F, Toldbod HE, Jensen JL, Ulhøi BP, Sengeløv L, Jensen KM, Ørntoft TF. Emmprin and Survivin Predict Response and Survival following Cisplatin-Containing Chemotherapy in Patients with Advanced Bladder Cancer. Clin Cancer Res. 2007 Aug 1;13(15):4407-14 PubMed Andersen CL, Schepeler T, Thorsen K, Birkenkamp-Demtröder K, Mansilla F, Aaltonen LA, Laurberg S, Ørntoft TF. Clusterin expression in normal mucosa and colorectal cancer. Mol Cell Proteomics. 2007 Jun;6(6):1039-48. Epub 2007 Feb 23. PubMed Bergholdt R, Karlsen AE, Hagedorn PH, Aalund M, Nielsen JH, Kruhoffer M, Orntoft T, Wang H, Wollheim CB, Nerup J, Pociot F. Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets. Genes Immun. 2007 Apr;8(3):232-8. Epub 2007 Mar 1. PubMed Birkenkamp-Demtroder, K., Mansilla, F., Sørensen F.B., Kruhoeffer, M., Christensen, L.L., Aaltonen, L.A., Verspaget, H.W. and Ørntoft T.F. Phosphoprotein Keratin 23 accumulates in MSS but not MSI colon cancers in vivo and impacts viability and proliferation in vitro. Mol Oncol. 2007 Sep;1(2):181-95. Epub 2007 Jun 3. PubMed Daugaard M, Kirkegaard-Sorensen T, Ostenfeld MS, Aaboe M, Hoyer-Hansen M, Orntoft TF, Rohde M, Jaattela M. Lens Epithelium-Derived Growth Factor Is an Hsp70-2 Regulated Guardian of Lysosomal Stability in Human Cancer. Cancer Res. 2007 Mar 15;67(6):2559-2567. PubMed De Martino I, Visone R, Palmieri D, Cappabianca P, Chieffi P, Forzati F, Barbieri A, Kruhoffer M, Lombardi G, Fusco A, Fedele M. The Mia/Cd-rap gene expression is downregulated by the high-mobility group A proteins in mouse pituitary adenomas. Endocr Relat Cancer. 2007 Sep;14(3):875-886. PubMed Dyrskjot L, Zieger K, Orntoft TF. Recent advances in high-throughput molecular marker identification for superficial and invasive bladder cancers. Front Biosci. 2007 Jan 1;12:2063-73. Review. PubMed Dyrskjot L, Zieger K, Real FX, Malats N, Carrato A, Hurst C, Kotwal S, Knowles M, Malmstrom PU, de la Torre M, Wester K, Allory Y, Vordos D, Caillault A, Radvanyi F, Hein AM, Jensen JL, Jensen KM, Marcussen N, Orntoft TF. Gene expression signatures predict outcome in non-muscle-invasive bladder carcinoma: a multicenter validation study. Clin Cancer Res. 2007 Jun 15;13(12):3545-51. PubMed Ehlers N, Hjortdal J, Nielsen K, Thiel HJ, Orntoft T. Phenotypic variability in Meesmann's dystrophy: clinical review of the literature and presentation of a family genetically identical to the original family. Acta Ophthalmol Scand. 2007 Nov 6. PubMed Kruhoffer M, Dyrskjot L, Voss T, Lindberg RL, Wyrich R, Thykjaer T, Orntoft TF. Isolation of Microarray-Grade Total RNA, MicroRNA, and DNA from a Single PAXgene Blood RNA Tube. J Mol Diagn. 2007 [Epub ahead of print] PubMed Lamy P, Andersen CL, Dyrskjot L, Torring N, Wiuf C. A Hidden Markov Model to estimate population mixture and allelic copy-numbers in cancers using Affymetrix SNP arrays. BMC Bioinformatics. 2007 Nov 9;8(1):434. PubMed Larsen PF, Nielsen EE, Williams TD, Hemmer-Hansen J, Chipman JK, Kruhoffer M, Gronkjaer P, George SG, Dyrskjot L, Loeschcke V. Adaptive differences in gene expression in European flounder (Platichthys flesus). Mol Ecol. 2007 Oct 8; [Epub ahead of print] PubMed Mansilla, F., Wang, S., da Costa, K.A., Kruhøffer, M., Lewin, T.M., Ørntoft,T.F., Coleman, R.A. and Birkenkamp-Demtroder, K. (2007) From microarray analysis to protein function: Overexpression of LPCAT1 in colorectal cancer. Journal of Biotechnology, Volume 131, Issue 2, Supplement 1 Mansilla F, Birkenkamp-Demtroder K, Kruhoffer M, Sorensen FB, Andersen CL, Laiho P, Aaltonen LA, Verspaget HW, Orntoft TF. Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups. Br J Cancer. 2007 96(12):1896-1903. Epub 2007 May 22. PubMed Niemelä AM, Hynninen P, Mecklin JP, Kuopio T, Kokko A, Aaltonen L, Parkkila AK, Pastorekova S, Pastorek J, Waheed A, Sly WS, Orntoft TF, Kruhøffer M, Haapasalo H, Parkkila S, Kivelä AJ. Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1760-6. PubMed Pirot P, Naamane N, Libert F, Magnusson NE, Orntoft TF, Cardozo AK, Eizirik DL. Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs. Diabetologia. 2007 May;50(5):1006-14. Epub 2007 Mar 1. PubMed Raitila A, Georgitsi M, Karhu A, Tuppurainen K, Makinen MJ, Birkenkamp-Demtroder K, Salmenkivi K, Orntoft TF, Arola J, Launonen V, Vahteristo P, Aaltonen LA. No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia. Endocr Relat Cancer. 2007 Sep;14(3):901-6. PubMed Salvig JD, Winding TN, Henriksen TB, Torring N, Pedersen OB, Uldbjerg N. PAPP-A and fetal growth from week 12 to week 20. Ultrasound Obstet Gynecol. 2007 Sep 21;30(4):460 PubMed Schepeler T, Mansilla F, Christensen LL, Orntoft TF, Andersen CL. Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling. J Mol Signal. 2007 Jul 16;2:6. PubMed Sorensen KD, Borre M, Orntoft TF, Dyrskjot L, Torring N. Chromosomal deletion, promoter hypermethylation and downregulation of FYN in prostate cancer. Int J Cancer. 2007 Oct 17; [Epub ahead of print] PubMed Torring N, Borre M, Sorensen KD, Andersen CL, Wiuf C, Orntoft TF. Genome-wide analysis of allelic imbalance in prostate cancer using the Affymetrix 50K SNP mapping array. Br J Cancer. 2007 Feb 12;96(3):499-506. Epub 2007 Jan 23. PubMed Visconti R, Federico A, Coppola V, Pentimalli F, Berlingieri MT, Pallante P, Kruhoffer M, Orntoft TF, Fusco A. Transcriptional profile of Ki-Ras-induced transformation of thyroid cells. Cancer Invest. 2007 Jun;25(4):256-66. PubMed 2006 According to JCR Science Edition 2005, the total impact factor of these 21 publications is 140, with 17 publications with an impact factor above 2.5. Aaboe M, Birkenkamp-Demtroder K, Wiuf C, Sørensen FB, Thykjaer T, Sauter G, Møller-Ernst Jensen K, Dyrskjøt L, Ørntoft TF. SOX4 expression in bladder carcinoma: clinical aspects and in vitro functional characterization. Cancer Research. 2006. Apr 1;66(7):3434-42. PubMed Suppl Data Andersen CL, Wiuf C, Kruhoffer M, Korsgaard M, Laurberg, S and Orntoft TF. Frequent occurrence of uniparental disomy in colorectal cancer. Carcinogenesis. 2007 Jan;28(1):38-48. Epub 2006 Jun 13. PubMed Andersen JB, Aaboe M, Borden EC, Goloubeva OG, Hassel BA, Ørntoft TF. Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer. Br J Cancer. 2006 May 22;94(10):1465-71. PubMed Bartkova J, Rezaei N, Liontos M, Karakaidos P, Kletsas D, Issaeva N, Vassiliou LV, Kolettas E, Niforou K, Zoumpourlis VC, Takaoka M, Nakagawa H, Tort F, Fugger K, Johansson F, Sehested M, Andersen CL, Dyrskjot L, Orntoft T, Lukas J, Kittas C, Helleday T, Halazonetis TD, Bartek J, Gorgoulis VG. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature. 2006 Nov 30;444(7119):633-7. PubMed Colombo M, Kruhoeffer M, Gregersen S, Agger A, Jeppesen P, Oerntoft T, Hermansen K. Energy restriction prevents the development of type 2 diabetes in Zucker diabetic fatty rats: coordinated patterns of gene expression for energy metabolism in insulin-sensitive tissues and pancreatic islets determined by oligonucleotide microarray analysis. Metabolism. 2006 Jan;55(1):43-52. PubMed Suppl Data Dahl C, Saito H, Kruhoffer M, Schiotz PO . Identification of tryptase- and chymase-related gene clusters in human mast cells using microarrays. Allergy. 2006 Mar;61(3):276-80. PubMed Ebbesen LS, Olesen SH, Kruhoffer M, Ingerslev J, Orntoft TF. Folate deficiency induced hyperhomocysteinemia changes the expression of thrombosis-related genes. Blood Coagul Fibrinolysis. 2006 Jun;17(4):293-301. PubMed Frohlich C, Albrechtsen R, Dyrskjot L, Rudkjaer L, Orntoft TF, Wewer UM. Molecular Profiling of ADAM12 in Human Bladder Cancer. Clin Cancer Res. 2006 Dec 15;12(24):7359-7368. PubMed Gaustadnes M, Orntoft TF, Jensen JL, Torring N. Validation of the use of DNA pools and primer extension in association studies of sporadic colorectal cancer for selection of candidate SNPs. Hum Mutat. 2006 Feb;27(2):187-94. PubMed Holten-Andersen MN, Brunner N, Nielsen HJ, Christensen IJ, Sorensen NM, Rasmussen AS, Primdahl H, Orntoft T. Levels of tissue inhibitor of metalloproteinases 1 in plasma and urine from patients with bladder cancer. Int J Biol Markers. 2006 Jan-Mar;21(1):6-11. PubMed Kristensen TN , Sorensen P, Pedersen KS , Kruhoffer M, Loeschcke V. Inbreeding by environment interactions affect gene expression in Drosophila melanogaster. Genetics. 2006 Jul;173(3):1329-36. Epub 2006 Apr 19. PubMed Lamy P, Andersen CL, Dyrskjot L, Torring N, Orntoft T, Wiuf C. Are microRNAs located in genomic regions associated with cancer? Br J Cancer. 2006 Nov 20;95(10):1415-8. Epub 2006 Sep 26. PubMed Marcheco-Teruel B, Flint TJ, Wikman FP, Torralbas M, Gonzalez L, Blanco L, Tan Q, Ewald H, Orntoft T, Kruse TA, Borglum AD, Mors O. A genome-wide linkage search for bipolar disorder susceptibility loci in a large and complex pedigree from the eastern part of Cuba . Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141(8):833-43. PubMed Memon AA, Sorensen BS, Meldgaard P, Fokdal L, Thykjaer T, Nexo E. The relation between survival and expression of HER1 and HER2 depends on the expression of HER3 and HER4: a study in bladder cancer patients. Br J Cancer. 2006 Jun 5;94(11):1703-9. PubMed Nielsen K, Vorum H, Fagerholm P, Birkenkamp-Demtroder K, Honore B, Ehlers N, Orntoft TF. Proteome Profiling of Corneal Epithelium and Identification of Marker Proteins for Keratoconus, a pilot study. Exp Eye Res. 2006 Feb;82(2):201-9. Epub 2005 Aug 3. PubMed Nielsen MM, Sorensen JG, Kruhoffer M, Justesen J, Loeschcke V. Phototransduction genes are up-regulated in a global gene expression study of Drosophila melanogaster selected for heat resistance. Cell Stress Chaperones. 2006 Winter;11(4):325-33. PubMed Orntoft TF, Zieger K, Dyrskjot L. Recent developments in molecular profiling of bladder cancer. Curr Opin Urol. 2006 Sep;16(5):377-81. Review. PubMed Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H, Boix-Chornet M, Caballero R, Alaminos M, Setien F, Paz MF, Herranz M, Palacios J, Arango D, Orntoft TF, Aaltonen LA, Schwartz S , Esteller M. A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nat Genet. 2006 May;38(5):566-9. Epub 2006 Apr 16. PubMed Tort F, Bartkova J, Sehested M, Orntoft T, Lukas J, Bartek J. Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis. Cancer Res. 2006 Nov 1;66(21):10258-63. PubMed Vanharanta S, Pollard PJ, Lehtonen HJ, Laiho P, Sjoberg J, Leminen A, Aittomaki K, Arola J, Kruhoffer M, Orntoft TF, Tomlinson IP, Kiuru M, Arango D, Aaltonen LA: Distinct expression profile in fumarate-hydratase-deficient uterine fibroids. Hum Mol Genet. 2006 Jan 1;15(1):97-103. Epub 2005 Nov 30. PubMed Vestergaard EM, Borre M, Poulsen SS, Nexo E, Torring N. Plasma levels of trefoil factors are increased in patients with advanced prostate cancer. Clinical Cancer Research. 2006 Feb 1;12( 3 Pt 1):807-12. PubMed Ylisaukko-Oja SK, Cybulski C, Lehtonen R, Kiuru M, Matyjasik J, Szymanska A, Szymanska-Pasternak J, Dyrskjot L, Butzow R, Orntoft TF, Launonen V, Lubinski J, Aaltonen LA. Germline fumarate hydratase mutations in patients with ovarian mucinous cystadenoma. Eur J Hum Genet. 2006 Jul;14(7):880-3. Epub 2006 Apr 26. PubMed 2005 According to JCR Science Edition 2005, the total impact factor of these 26 publications is 156, with 20 publications with an impact factor above 2.5. Aaboe M, Marcussen N, Jensen KM, Thykjaer T, Dyrskjot L, Orntoft TF. Gene expression profiling of noninvasive primary urothelial tumours using microarrays. Br J Cancer. 2005. Nov 14;93(10):1182-90. PubMed Suppl Data Andersen C.L., Jacobsen E., Gruszka A., Matutes E., Catovsky D., Koch J. : Recurrent genomic imbalances in B-cell splenic marginal zone lymphoma revealed by comparative genomic hybridization. Cancer genetics and Cytogenetics. 2005; 156(2):122-128. PubMed Bartkova,J., Horejsi,Z., Koed,K., Kramer,A., Tort,F., Zieger,K., Guldberg,P., Sehested,M., Nesland,J.M., Lukas,C., Orntoft,T., Lukas,J., Bartek,J. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature. 434(7035): 864-870. 2005. PubMed Birkenkamp-Demtröder, K., Olesen, S.H., Sørensen,F.B., Laurberg, S., Laiho, P., Aaltonen, L.A., and Ørntoft, T.F. Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. Gut. 2005. Mar;54(3):374-84 PubMed Birkenkamp-Demtröder K, Wagner L, Sørensen FB, Astrup LB, Gartner W, Scherübl H, Heine B, Christiansen P, Ørntoft TF. Secretagogin is a novel marker for neuroendocrine differentiation. Neuroendocrinology. 2005;82(2):121-38. Epub 2006 Jan 30 PubMed Colombo M, Gregersen S, Kruhoeffer M, Agger A, Xiao J, Jeppesen PB, Orntoft T, Ploug T, Galbo H, Hermansen K. Prevention of hyperglycemia in Zucker diabetic fatty rats by exercise training: effects on gene expression in insulin-sensitive tissues determined by high-density oligonucleotide microarray analysis, Metabolism, 54 (12): 1571-81, 2005. PubMed Suppl Data Dyrskjøt L, Zieger K, Kruhøffer M, Thykjaer T, Jensen JL, Primdahl H, Aziz N, Marcussen N, Møller K and Ørntoft TF. A molecular signature in superficial bladder carcinoma predicts clinical outcome. Clinical Cancer Research. 2005. June 1, 11 (11): PubMed Suppl Data Enver,T., Soneji,S., Joshi,C., Brown,J., Iborra,F., Orntoft,T., Thykjaer,T., Maltby,E., Smith,K., Abu,D.R., Jones,M., Matin,M., Gokhale,P., Draper,J. and Andrews,P.W. Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells. Hum Mol Genet. 2005 Nov 1;14(21):3129-40. Epub 2005 Sep 13. PubMed Eschrich,S., Yang,I., Bloom,G., Kwong,K.Y., Boulware,D., Cantor,A., Coppola,D., Kruhoffer,M., Aaltonen,L., Orntoft,T.F., Quackenbush,J., Yeatman,T.J. Molecular staging for survival prediction of colorectal cancer patients. J Clin.Oncol.. 23(15): 3526-3535. 2005. PubMed Ewald,H., Wikman,F.P., Teruel,B.M., Buttenschon,H.N., Torralba,M., Als,T.D., El,Daoud A., Flint,T.J., Jorgensen,T.H., Blanco,L., Kruse,T.A., Orntoft,T.F., Mors,O. A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder. Am.J Med Genet.B Neuropsychiatr.Genet.. 133(1): 25-30. 2005. PubMed Harnacke K, Kruhoffer M, Orntoft TF, Hass R. Down-modulation of poly(ADP-ribose) polymerase-1 (PARP-1) in human TUR leukemia cells restores transcriptional responsiveness for differentiation and cell cycle arrest. Eur J Cell Biol. 2005 Nov;84(11):885-96. PubMed Kalbe,L., Leunda,A., Sparre,T., Meulemans,C., Ahn,M.T., Orntoft,T., Kruhoffer,M., Reusens,B., Nerup,J., Remacle,C. Nutritional regulation of proteases involved in fetal rat insulin secretion and islet cell proliferation. Br.J Nutr.. 93(3): 309-316. 2005. PubMed Koed, K., Wiuf,C., Christensen, L.L., Wikman, F., Zieger, K., Møller, K., von der Maase, H., Ørntoft, T.F. High-density single nucleotide polymorphism array defines novel stage and location-dependent allelic imbalances in human bladder tumors. Cancer Research. 2005. 65 (1):34-45. PubMed Suppl data Kristensen TN, Sørensen P, Kruhøffer M, Pedersen KS, and Loeschcke V. Genome wide analysis on inbreeding effects on gene expression in Drosophila melanogaster. Genetics. 2005 Sep;171(1):157-67. Epub 2005 Jun 8. PubMed Kruhøffer, M., Jensen J.L., Laiho, P., Dyrskjøt, L., Salovaara, R., Arango, D., Birkenkamp-Demtroder, K., Christensen, L.L., Sørensen, F.B., Buhl, L., Mecklin J-P., Järvinen, H., Thykjaer, T., Wikman, F.P., Bech-Knudsen, F., Juhola, M., Nupponen, N.N., Lauerberg, S., Andersen, C.L., Aaltonen, L.A. and Ørntoft, T.F. (2005) Gene expression signatures for colorectal cancer microsatellite status and HNPCC. British Journal of Cancer. 2005 Jun 20;92(12):2240-8. PubMed Lund,L., Moller Ernst-Jensen,K., Torring,N. and Erik,N.J. Impact of finasteride treatment on perioperative bleeding before transurethral resection of the prostate: a prospective randomized study, Scand.J Urol.Nephrol., 39: 160-162, 2005. PubMed Magnusson NE, Cardozo AK, Kruhoffer M, Eizirik DL, Orntoft TF, Jensen JL. Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis. BMC Bioinformatics. 2005 Dec 29;6(1):311 [Epub ahead of print] PubMed Magnusson,N.E., Larsen,A., Rungby,J., Kruhoffer,M., Orntoft,T.F., Stoltenberg,M. Gene expression changes induced by bismuth in a macrophage cell line. Cell Tissue Res. 2005 Aug;321(2):195-210. Epub 2005 May 24. PubMed Melillo,R.M., Castellone,M.D., Guarino,V., De,Falco,V, Cirafici,A.M., Salvatore,G., Caiazzo,F., Basolo,F., Giannini,R., Kruhoffer,M., Orntoft,T., Fusco,A., Santoro,M. The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells. J Clin.Invest. (021-9738): . 2005. PubMed Nielsen,K., Heegaard,S., Vorum,H., Birkenkamp-Demtroeder,K., Ehlers,N., Orntoft,T. Altered gene and protein expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients. Cornea. 2005 Aug;24(6):661-8. PubMed Olesen, S.H., Christensen, L.L., Sørensen, F.B., Cabezon, T., Laurberg, S., Ørntoft, T.F., Birkenkamp-Demtröder, K. Human FK506 binding protein 65 is associated with colorectal cancer. Mol Cell Proteomics. 2005, Jan 25 (Epub ahead of print). PubMed Orntoft,T.F. [Genomic classification of diseases], Ugeskr.Laeger, 167: 2164-2167, 2005 PubMed Pallante,P., Berlingieri,M.T., Troncone,G., Kruhoffer,M., Orntoft,T.F., Viglietto,G., Caleo,A., Migliaccio,I., caussin-Petrucci,M., Santoro,M., Palombini,L. and Fusco,A. UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas, Br.J Cancer, 93: 464-471, 2005. PubMed Ripa,R.S., Katballe,N., Wikman,F.P., Jager,A.C., Bernstein,I., Orntoft,T., Schwartz,M., Nielsen,F.C., Bisgaard,M.L. Presymptomatic diagnosis using a deletion of a single codon in families with hereditary non-polyposis colorectal cancer. Mutat.Res.. 570(1): 89-96. 2005. PubMed Sorensen JG, Nielsen MM, Kruhoffer M, Justesen J, Loeschcke V. Full genome gene expression analysis of the heat stress response in Drosophila melanogaster. Cell Stress Chaperones. 2005 Winter;10(4):312-28. PubMed Torring,N., Hansen,F.D., Sorensen,B.S., Orntoft,T.F. and Nexo,E. Increase in amphiregulin and epiregulin in prostate cancer xenograft after androgen deprivation-impact of specific HER1 inhibition, Prostate. 2005; Jun 15;64(1):1-8 PubMed Zieger K, Dyrskjot L, Wiuf C, Jensen JL, Andersen CL, Jensen KM, Orntoft TF. Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors. Clin Cancer Res. 2005 Nov 1;11(21):7709-19. PubMed
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