2011

Abildgaard MO, Borre M, Mørck Mortensen M, Ulhøi BP, Tørring N, Wild P, Kristensen H, Mansilla F, Ottosen PD, Dyrskjøt L, Orntoft TF, Dalsgaard Sørensen K.
Downregulation of ZNF132 in prostate cancer is associated with aberrant promoter hypermethylation and poor prognosis.
Int J Cancer. 2012 Feb 15;130(4):885-95. doi: 10.1002/ijc.26097. Epub 2011 May 25. PubMed

Alhopuro P, Sammalkorpi H, Niittymäki I, Biström M, Raitila A, Saharinen J, Nousiainen K, Lehtonen HJ, Heliövaara E, Puhakka J, Tuupanen S, Sousa S, Seruca R, Ferreira AM, Hofstra RM, Mecklin JP, Järvinen H, Ristimäki A, Orntoft TF, Hautaniemi S, Arango D, Karhu A, Aaltonen LA.
Candidate driver genes in microsatellite-unstable colorectal cancer.
Int J Cancer. 2011 May 4. doi: 10.1002/ijc.26167. [Epub ahead of print] PubMed

Andersen CL, Lamy P, Orntoft TF.
Are CIMP and chr16p13.2 copy number status independent prognostic markers in stage II and III colorectal cancer? Int J Cancer. 2012 Jan 1;130(1):243. doi: 10.1002/ijc.25998. Epub 2011 Apr 25. PubMed

Baandrup JD, Markvardsen LH, Peters CD, Schou UK, Jensen JL, Magnusson NE, Orntoft TF, Kruhøffer M, Simonsen U.
Pressure load: the main factor for altered gene expression in right ventricular hypertrophy in chronic hypoxic rats.
PLoS One. 2011 Jan 5;6(1):e15859. PubMed

Birkenkamp-Demtroder K, Maghnouj A, Mansilla F, Thorsen K, Andersen CL, Øster B, Hahn S and Ørntoft TF.
Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells.
Br J Cancer. 2011 Jul 19. doi: 10.1038/bjc.2011.268. [Epub ahead of print] PubMed

Hansen TF, Andersen CL, Nielsen BS, Spindler KLG, Sørensen FB, Lindebjerg J, Brandslund I, Jakobsen A.
Elevated microRNA-126 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in colorectal cancer.
Oncology Letters. 2011. Epub Aug 4. doi

Henriksen R, Sørensen FB, Orntoft TF, Birkenkamp-Demtroder K.
Expression of FK506 binding protein 65 (FKBP65) is decreased in epithelial ovarian cancer cells compared to benign tumor cells and to ovarian epithelium.
Tumour Biol. 2011 Aug;32(4):671-6. Epub 2011 Mar 12. PubMed

Hollegaard MV, Grove J, Grauholm J, Kreiner-Møller E, Bønnelykke K, Nørgaard M, Benfield TL, Nørgaard-Pedersen B, Mortensen PB, Mors O, Sørensen HT, Harboe ZB, Børglum AD, Demontis D, Ørntoft TF, Bisgaard H, Hougaard DM.
Robustness of genome-wide scanning using archived dried blood spot samples as a DNA source.
BMC Genet. 2011 Jul 4;12:58. PubMed

Jensen JB, Munksgaard PP, Sørensen CM, Fristrup N, Birkenkamp-Demtroder K, Ulhøi BP, Jensen KM, Orntoft TF, Dyrskjøt L.
High Expression of Karyopherin-α2 Defines Poor Prognosis in Non-Muscle-Invasive Bladder Cancer and in Patients with Invasive Bladder Cancer Undergoing Radical Cystectomy.
Eur Urol. 2011 Feb 15. [Epub ahead of print] PubMed

Jensen SG, Lamy P, Rasmussen MH, Ostenfeld MS, Dyrskjot L, Orntoft TF, Andersen CL.
Evaluation of two commercial global miRNA expression profiling platforms for detection of less abundant miRNAs. BMC Genomics. 2011 Aug 26;12(1):435. PubMed

Zsofia Kote-Jarai, Ali Amin Al Olama, Graham G. Giles,, Gianluca Severi,, Johanna Schleutker, Maren Weischer, Frederico Canzian, Elio Riboli,,Tim Key, Henrik Gronberg, David J.Hunter, Peter Kraft, Michael J Thun, Sue Ingles, Stephen Chanock, Demetrius Albanes, Richard B Hayes, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, Paul Pharoah, Fredrick Schumacher, Brian E. Henderson, Janet L. Stanford , Elaine A. Ostrander, Karina Dalsgaard Sorensen, Thilo Dörk, Gerald Andriole, Joanne L. Dickinson, Cezary Cybulski, Jan Lubinski, Amanda Spurdle, Judith A. Clements, Suzanne Chambers, Joanne Aitken, R.A. Frank Gardiner, Stephen N. Thibodeau, Dan Schaid, Esther M. John, Christiane Maier, Walther Vogel, Kathleen A. Cooney, Jong Y. Park, Lisa Cannon-Albright,, Hermann Brenner, Tomonori Habuchi, Hong-Wei Zhang, Yong-Jie Lu, Radka Kaneva, Ken Muir, Sara Benlloch, Daniel A. Leongamornlert, Edward J. Saunders Malgorzata Tymrakiewicz, Nadiya Mahmud, Michelle Guy, Lynne T. O'Brien, Rosemary A. Wilkinson, Amanda L. Hall, Emma J. Sawyer, Tokhir Dadaev, Jonathan Morrison, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas Van As, Christopher J. Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin S. Cooper, Aritaya Lophatonanon, Melissa C. Southey, John L. Hopper, Dallas English, Tiina Wahlfors, Teuvo LJ Tammela, Peter Klarskov, Børge G. Nordestgaard, M. Andreas Røder, Anne Tybjærg-Hansen, Stig E. Bojesen, Ruth Travis, Daniele Campa, Rudolf Kaaks, Fredrik Wiklund, Markus Aly, Sara Lindstrom, W Ryan Diver, Susan Gapstur, Mariana C Stern, Roman Corral, Jarmo Virtamo, Angela Cox, Christopher A. Haiman, Loic Le Marchand, Liesel FitzGerald, Suzanne Kolb, Erika M. Kwon, Danielle M. Karyadi, Torben Falck Orntoft, Michael Borre, Andreas Meyer, Jürgen Serth, Meredith Yeager, Sonja I. Berndt, James R Marthick, Briony Patterson, Dominika Wokolorczyk, Jyotsna Batra, Felicity Lose, Shannon K McDonnell, Amit D. Joshi, Ahva Shahabi, Antje E. Rinckleb, Ana Ray, Thomas A. Sellers, Huo-Yi Lin, Robert A Stephenson, James Farnham, Heiko Muller, Dietrich Rothenbacher, Norihiko Tsuchiya, Shintaro Narita, Guang-Wen Cao, Chavdar Slavov, Vanio Mitev, The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, The UK ProtecT Study Collaborators, The PRACTICAL Consortium, Douglas F. Easton, Rosalind A. Eeles.
Seven novel prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Nat Genet. 2011 Jul 10;43(8):785-791. PubMed

Lamy P, Grove J, Wiuf C.
A review of software for microarray genotyping.
Hum Genomics. 2011 May 1;5(4):304-9. PubMed

Laurila K, Oster B, Andersen CL, Lamy P, Orntoft T, Yli-Harja O, Wiuf C.
A Beta-Mixture Model for Dimensionality Reduction, Sample Classification and Analysis.
BMC Bioinformatics. 2011 May 27;12(1):215. [Epub ahead of print] PubMed

Mansilla, F., Andersen, L. D., Brems-Eskildsen, A. S., Fristrup, N., Thorsen, K., Madsen, P. P., Dalsgaard Sørensen, K., Borre, M., Ørntoft, T. F. & Birkenkamp-Demtröder, K.
TOX3 (TNRC9) is differentially expressed in muscle invasive human bladder cancer and elicits an interferone like response
BMC Cancer. 2011. In press

Munksgaard PP, Mansilla F, Brems Eskildsen AS, Fristrup N, Birkenkamp-Demtröder K, Ulhøi BP, Borre M, Agerbæk M, Hermann GG, Orntoft TF, Dyrskjøt L.
Low ANXA10 expression is associated with disease aggressiveness in bladder cancer.
Br J Cancer. 2011 Oct 25;105(9):1379-87. doi: 10.1038/bjc.2011.404. Epub 2011 Oct 6. PubMed

Nordentoft IK, Andersen LD, Bødker JS, Wild P, Hartmann A, Bertz S, Lehmann J, Ørntoft TF, Birkenkamp-Demtröder K.
Increased expression of Transcription Factor TFAP2 alpha correlates with chemosensitivity in advanced bladder cancer.
BMC Cancer. 2011 Apr 14;11(1):135. [Epub ahead of print] PubMed

Orntoft TF.
Personalised treatment for bladder cancer.
Lancet Oncol. 2011 Feb;12(2):111-2. Epub 2011 Jan 20. PubMed

Oster B, Thorsen K, Lamy P, Wojdacz TK, Hansen LL, Birkenkamp-Demtröder K, Sørensen KD, Laurberg S, Orntoft TF, Andersen CL.
Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas
Int J Cancer. 2011 Dec 15;129(12):2855-66. doi: 10.1002/ijc.25951. Epub 2011 Apr 1. PubMed

Reinert T, Modin C, Mansilla F, Lamy P, Wojdacz TK, Hansen LL, Wiuf C, Borre M, Dyrskjøt L, and Orntoft TF.
Comprehensive Genome Methylation Analysis in Bladder Cancer; Identification and Validation of Novel Methylated Genes and Application of These As Urinary Tumor Markers.
Clin Cancer Res. 2011 Sep 1;17(17):5582-92. Epub 2011 Jul 25. PubMed

Schepeler T, Holm A, Halvey P, Nordentoft I, Lamy P, Riising EM, Christensen LL, Thorsen K, Liebler DC, Helin K, Orntoft TF, Andersen CL.
Attenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes.
Oncogene. 2011 Oct 3. doi: 10.1038/onc.2011.453. [Epub ahead of print] PubMed

The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium, Ripke S, Sanders AR, Kendler KS, Levinson DF, Sklar P, Holmans PA, Lin DY, Duan J, Ophoff RA, Andreassen OA, Scolnick E, Cichon S, St Clair D, Corvin A, Gurling H, Werge T, Rujescu D, Blackwood DH, Pato CN, Malhotra AK, Purcell S, Dudbridge F, Neale BM, Rossin L, Visscher PM, Posthuma D, Ruderfer DM, Fanous A, Stefansson H, Steinberg S, Mowry BJ, Golimbet V, De Hert M, Jönsson EG, Bitter I, Pietiläinen OP, Collier DA, Tosato S, Agartz I, Albus M, Alexander M, Amdur RL, Amin F, Bass N, Bergen SE, Black DW, Børglum AD, Brown MA, Bruggeman R, Buccola NG, Byerley WF, Cahn W, Cantor RM, Carr VJ, Catts SV, Choudhury K, Cloninger CR, Cormican P, Craddock N, Danoy PA, Datta S, de Haan L, Demontis D, Dikeos D, Djurovic S, Donnelly P, Donohoe G, Duong L, Dwyer S, Fink-Jensen A, Freedman R, Freimer NB, Friedl M, Georgieva L, Giegling I, Gill M, Glenthøj B, Godard S, Hamshere M, Hansen M, Hansen T, Hartmann AM, Henskens FA, Hougaard DM, Hultman CM, Ingason A, Jablensky AV, Jakobsen KD, Jay M, Jürgens G, Kahn RS, Keller MC, Kenis G, Kenny E, Kim Y, Kirov GK, Konnerth H, Konte B, Krabbendam L, Krasucki R, Lasseter VK, Laurent C, Lawrence J, Lencz T, Lerer FB, Liang KY, Lichtenstein P, Lieberman JA, Linszen DH, Lönnqvist J, Loughland CM, Maclean AW, Maher BS, Maier W, Mallet J, Malloy P, Mattheisen M, Mattingsdal M, McGhee KA, McGrath JJ, McIntosh A, McLean DE, McQuillin A, Melle I, Michie PT, Milanova V, Morris DW, Mors O, Mortensen PB, Moskvina V, Muglia P, Myin-Germeys I, Nertney DA, Nestadt G, Nielsen J, Nikolov I, Nordentoft M, Norton N, Nöthen MM, O'Dushlaine CT, Olincy A, Olsen L, O'Neill FA, Orntoft TF, Owen MJ, Pantelis C, Papadimitriou G, Pato MT, Peltonen L, Petursson H, Pickard B, Pimm J, Pulver AE, Puri V, Quested D, Quinn EM, Rasmussen HB, Réthelyi JM, Ribble R, Rietschel M, Riley BP, Ruggeri M, Schall U, Schulze TG, Schwab SG, Scott RJ, Shi J, Sigurdsson E, Silverman JM, Spencer CC, Stefansson K, Strange A, Strengman E, Stroup TS, Suvisaari J, Terenius L, Thirumalai S, Thygesen JH, Timm S, Toncheva D, van den Oord E, van Os J, van Winkel R, Veldink J, Walsh D, Wang AG, Wiersma D, Wildenauer DB, Williams HJ, Williams NM, Wormley B, Zammit S, Sullivan PF, O'Donovan MC, Daly MJ, Gejman PV.
Genome-wide association study identifies five new schizophrenia loci.
Nat Genet. 2011 Sep 18;43(10):969-76. doi: 10.1038/ng.940. PubMed

Steinberg S, de Jong S; Irish Schizophrenia Genomics Consortium, Andreassen OA, Werge T, Børglum AD, Mors O, Mortensen PB, Gustafsson O, Costas J, Pietiläinen OP, Demontis D, Papiol S, Huttenlocher J, Mattheisen M, Breuer R, Vassos E, Giegling I, Fraser G, Walker N, Tuulio-Henriksson A, Suvisaari J, Lönnqvist J, Paunio T, Agartz I, Melle I, Djurovic S, Strengman E; GROUP, Jürgens G, Glenthøj B, Terenius L, Hougaard DM, Orntoft T, Wiuf C, Didriksen M, Hollegaard MV, Nordentoft M, van Winkel R, Kenis G, Abramova L, Kaleda V, Arrojo M, Sanjuán J, Arango C, Sperling S, Rossner M, Ribolsi M, Magni V, Siracusano A, Christiansen C, Kiemeney LA, Veldink J, van den Berg L, Ingason A, Muglia P, Murray R, Nöthen MM, Sigurdsson E, Petursson H, Thorsteinsdottir U, Kong A, Rubino IA, De Hert M, Réthelyi JM, Bitter I, Jönsson EG, Golimbet V, Carracedo A, Ehrenreich H, Craddock N, Owen MJ, O'Donovan MC; Wellcome Trust Case Control Consortium, Ruggeri M, Tosato S, Peltonen L, Ophoff RA, Collier DA, St Clair D, Rietschel M, Cichon S, Stefansson H, Rujescu D, Stefansson K.
Common Variants at VRK2 and TCF4 Conferring Risk of Schizophrenia.
Hum Mol Genet. 2011 Jul 26. [Epub ahead of print] PubMed

Thorsen K, Schepeler T, Oster B, Rasmussen MH, Vang S, Wang K, Hansen KQ, Lamy P, Pedersen JS, Eller A, Mansilla F, Laurila K, Wiuf C, Laurberg S, Dyrskjot L, Orntoft TF, Andersen CL.
Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis.
BMC Genomics. 2011 Oct 14;12(1):505. [Epub ahead of print] PubMed

Villadsen SB, Bramsen JB, Ostenfeld MS, Wiklund ED, Fristrup N, Gao S, Hansen TB, Jensen TI, Borre M, Orntoft TF, Dyrskjøt L, Kjems J.
The miR-143/-145 cluster regulates plasminogen activator inhibitor-1 in bladder cancer.
Br J Cancer. 2012 Jan 17;106(2):366-74. doi: 10.1038/bjc.2011.520. Epub 2011 Nov 22. PubMed

Wach S, Nolte E, Szczyrba J, Stöhr R, Hartmann A, Orntoft T, Dyrskjøt L, Eltze E, Wieland W, Keck B, Ekici AB, Grässer F, Wullich B.
MiRNA profiles of prostate carcinoma detected by multi-platform miRNA screening.
Int J Cancer. 2012 Feb 1;130(3):611-21. doi: 10.1002/ijc.26064. Epub 2011 May 9. PubMed

Wiklund ED, Bramsen JB, Hulf T, Dyrskjøt L, Ramanathan R, Hansen TB, Villadsen SB, Gao S, Ostenfeld MS, Borre M, Peter ME, Orntoft TF, Kjems J, Clark SJ.
Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer.
Int J Cancer. 2011 Mar 15;128(6):1327-34. doi: 10.1002/ijc.25461. PubMed