Dahl C, Saito H, Kruhoffer M, Schiotz PO. Identification of tryptase- and chymase-related gene clusters in human mast cells using microarrays. Allergy. 2006 Mar;61(3):276-80. PubMed

Magnusson NE, Cardozo AK, Kruhoffer MM, Eizirik DL, Orntoft TF, Jensen JL. Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis. BMC Bioinformatics. 2005 Dec 29;6(1):311 [Epub ahead of print] PubMed

Colombo M, Kruhoeffer M, Gregersen S, Agger A, Jeppesen P, Oerntoft T, Hermansen K. Energy restriction prevents the development of type 2 diabetes in Zucker diabetic fatty rats: coordinated patterns of gene expression for energy metabolism in insulin-sensitive tissues and pancreatic islets determined by oligonucleotide microarray analysis. Metabolism. 2006 Jan;55(1):43-52. PubMed Suppl Data

Vanharanta S, Pollard PJ, Lehtonen HJ, Laiho P, Sjoberg J, Leminen A, Aittomaki K, Arola J, Kruhoffer M, Orntoft TF, Tomlinson IP, Kiuru M, Arango D, Aaltonen LA: Distinct expression profile in fumarate-hydratase-deficient uterine fibroids. Hum Mol Genet 2006; 15(1):97-103. PubMed

Sorensen JG, Nielsen MM, Kruhoffer M, Justesen J, Loeschcke V. Full genome gene expression analysis of the heat stress response in Drosophila melanogaster. Cell Stress Chaperones. 2005 Winter;10(4):312-28. PubMed

Harnacke K, Kruhoffer M, Orntoft TF, Hass R. Down-modulation of poly(ADP-ribose) polymerase-1 (PARP-1) in human TUR leukemia cells restores transcriptional responsiveness for differentiation and cell cycle arrest. Eur J Cell Biol. 2005 Nov;84(11):885-96. PubMed

Colombo,M., Gregersen,S., Kruhoeffer,M., Agger,A., Xiao,J., Jeppesen,P.B., Orntoft,T., Ploug,T., Galbo,H. and Hermansen,K. Prevention of hyperglycemia in Zucker diabetic fatty rats by exercise training: effects on gene expression in insulin-sensitive tissues determined by high-density oligonucleotide microarray analysis, Metabolism, 54: 1571-1581, 2005. PubMed

Pallante,P., Berlingieri,M.T., Troncone,G., Kruhoffer,M., Orntoft,T.F., Viglietto,G., Caleo,A., Migliaccio,I., caussin-Petrucci,M., Santoro,M., Palombini,L. and Fusco,A. UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas, Br.J Cancer, 93: 464-471, 2005. PubMed

Kruhøffer, M., Jensen J.L., Laiho, P., Dyrskjøt, L., Salovaara, R., Arango, D., Birkenkamp-Demtroder, K., Christensen, L.L., Sørensen, F.B., Buhl, L., Mecklin J-P., Järvinen, H., Thykjaer, T., Wikman, F.P., Bech-Knudsen, F., Juhola, M., Nupponen, N.N., Lauerberg, S., Andersen, C.L., Aaltonen, L.A. and Ørntoft, T.F. (2005) Gene expression signatures for colorectal cancer microsatellite status and HNPCC. British Journal of Cancer. 2005 Jun 20;92(12):2240-8. PubMed

Dyrskjøt L, Zieger K, Kruhøffer M, Thykjaer T, Jensen JL, Primdahl H, Aziz N, Marcussen N, Møller K and Ørntoft TF. A molecular signature in superficial bladder carcinoma predicts clinical outcome. Clinical Cancer Research. 2005. June 1, 11 (11) PubMed Suppl Data

Kristensen TN, Sørensen P, Kruhøffer M, Pedersen KS, and Loeschcke V. Genome wide analysis on inbreeding effects on gene expression in Drosophila melanogaster. Genetics, 2005. June 8 (Epub ahead of print) PubMed

Magnusson,N.E., Larsen,A., Rungby,J., Kruhoffer,M., Orntoft,T.F., Stoltenberg,M. Gene expression changes induced by bismuth in a macrophage cell line. Cell Tissue Res.. (302-766X): . 2005. PubMed

Eschrich,S., Yang,I., Bloom,G., Kwong,K.Y., Boulware,D., Cantor,A., Coppola,D., Kruhoffer,M., Aaltonen,L., Orntoft,T.F., Quackenbush,J., Yeatman,T.J. Molecular staging for survival prediction of colorectal cancer patients. J Clin.Oncol.. 23(15): 3526-3535. 2005. PubMed

Kalbe,L., Leunda,A., Sparre,T., Meulemans,C., Ahn,M.T., Orntoft,T., Kruhoffer,M., Reusens,B., Nerup,J., Remacle,C. Nutritional regulation of proteases involved in fetal rat insulin secretion and islet cell proliferation. Br.J Nutr.. 93(3): 309-316. 2005. PubMed

Melillo,R.M., Castellone,M.D., Guarino,V., De,Falco,V, Cirafici,A.M., Salvatore,G., Caiazzo,F., Basolo,F., Giannini,R., Kruhoffer,M., Orntoft,T., Fusco,A., Santoro,M. The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells. J Clin.Invest. (021-9738): . 2005. PubMed

Castellone,M.D., Guarino,V., De,Falco,V, Carlomagno,F., Basolo,F., Faviana,P., Kruhoffer,M., Orntoft,T., Russell,J.P., Rothstein,J.L., Fusco,A., Santoro,M., Melillo,R.M. Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. Oncogene. 23(35): 5958-5967. 2004. PubMed

Castellone,M.D., Celetti,A., Guarino,V., Cirafici,A.M., Basolo,F., Giannini,R., Medico,E., Kruhoffer,M., Orntoft,T.F., Curcio,F., Fusco,A., Melillo,R.M., Santoro,M. Autocrine stimulation by osteopontin plays a pivotal role in the expression of the mitogenic and invasive phenotype of RET/PTC-transformed thyroid cells. Oncogene. 23(12): 2188-2196. 2004. PubMed

Dyrskjot,L., Kruhoffer,M., Thykjaer,T., Marcussen,N., Jensen,J.L., Moller,K., Orntoft,T.F. Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res.. 64(11): 4040-4048. 2004. PubMed

Karlsen,A.E., Heding,P.E., Frobose,H., Ronn,S.G., Kruhoffer,M., Orntoft,T.F., Darville,M., Eizirik,D.L., Pociot,F., Nerup,J., Mandrup-Poulsen,T., Billestrup,N. Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways. Diabetologia. 47(11): 1998-2011. 2004. PubMed

Lardon,J., De,Breuck S., Rooman,I., Van,Lommel L., Kruhoffer,M., Orntoft,T., Schuit,F., Bouwens,L. Plasticity in the adult rat pancreas: transdifferentiation of exocrine to hepatocyte-like cells in primary culture. Hepatology. 39(6): 1499-1507. 2004. PubMed

Martinez,Hoyos J., Fedele,M., Battista,S., Pentimalli,F., Kruhoffer,M., Arra,C., Orntoft,T.F., Croce,C.M., Fusco,A. Identification of the genes up- and down-regulated by the high mobility group A1 (HMGA1) proteins: tissue specificity of the HMGA1-dependent gene regulation. Cancer Res.. 64(16): 5728-5735. 2004. PubMed

Nielsen,K., Kruhoffer,M., Orntoft,T., Sparre,T., Wang,H., Wollheim,C., Jorgensen,M.C., Nerup,J., Karlsen,A.E. Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity. Diabetologia. 47(12): 2185-2199. 2004. PubMed

Vermijlen,D., Seynaeve,C., Luo,D., Kruhoffer,M., Eizirik,D.L., Orntoft,T.F., Wisse,E. High-density oligonucleotide array analysis reveals extensive differences between freshly isolated blood and hepatic natural killer cells. Eur.J Immunol.. 34(9): 2529-2540. 2004. PubMed

Cardozo,A.K., Berthou,L., Kruhoffer,M., Orntoft,T., Nicolls,M.R., Eizirik,D.L. Gene microarray study corroborates proteomic findings in rodent islet cells. J Proteome.Res.. 2(5): 553-555. 2003. PubMed

Dyrskjot,L., Thykjaer,T., Kruhoffer,M., Jensen,J.L., Marcussen,N., Hamilton-Dutoit,S., Wolf,H., Orntoft,T.F. Identifying distinct classes of bladder carcinoma using microarrays. Nat.Genet.. 33(1): 90-96. 2003. PubMed

Frederiksen,C.M., Aaboe,M., Dyrskjot,L., Laurberg,S., Wolf,H., Orntoft,T.F., Kruhoffer,M. Technical evaluation of cDNA microarrays. APMIS Suppl. (109): 96-101. 2003. PubMed

Jeppesen,P.B., Gregersen,S., Rolfsen,S.E., Jepsen,M., Colombo,M., Agger,A., Xiao,J., Kruhoffer,M., Orntoft,T., Hermansen,K. Antihyperglycemic and blood pressure-reducing effects of stevioside in the diabetic Goto-Kakizaki rat. Metabolism. 52(3): 372-378. 2003. PubMed

Kutlu,B., Cardozo,A.K., Darville,M.I., Kruhoffer,M., Magnusson,N., Orntoft,T., Eizirik,D.L. Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes. 52(11): 2701-2719. 2003. PubMed

Rasschaert,J., Liu,D., Kutlu,B., Cardozo,A.K., Kruhoffer,M., Orntoft,T.F., Eizirik,D.L. Global profiling of double stranded RNA- and IFN-gamma-induced genes in rat pancreatic beta cells. Diabetologia. 46(12): 1641-1657. 2003. PubMed

Vallat,L., Magdelenat,H., Merle-Beral,H., Masdehors,P., Potocki de,Montalk G., Davi,F., Kruhoffer,M., Sabatier,L., Orntoft,T.F., Delic,J. The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays. Blood. 101(11): 4598-4606. 2003. PubMed

Flamez,D., Berger,V., Kruhoffer,M., Orntoft,T., Pipeleers,D., Schuit,F.C. Critical role for cataplerosis via citrate in glucose-regulated insulin release. Diabetes. 51(7): 2018-2024. 2002. PubMed

Vermijlen,D., Luo,D., Kruhoffer,M., Orntoft,T.F., Kuppen,P.J., Wisse,E. Is the presence of interleukin-2 receptor alpha in the serum of colorectal liver metastases patients derived from hepatic natural killer cells?. Cancer Immunol.Immunother.. 51(5): 291-292. 2002. PubMed

Cardozo,A.K., Heimberg,H., Heremans,Y., Leeman,R., Kutlu,B., Kruhoffer,M., Orntoft,T., Eizirik,D.L. A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells. J Biol.Chem.. 276(52): 48879-48886. 2001. PubMed

Cardozo,A.K., Kruhoffer,M., Leeman,R., Orntoft,T., Eizirik,D.L. Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays. Diabetes. 50(5): 909-920. 2001. PubMed

Hirsch,J.R., Kruhoffer,M., Adermann,K., Heitland,A., Maronde,E., Meyer,M., Forssmann,W.G., Herter,P., Plenz,G., Schlatter,E. Cellular localization, membrane distribution, and possible function of guanylyl cyclases A and 1 in collecting ducts of rat. Cardiovasc.Res.. 51(3): 553-561. 2001. PubMed

Thykjaer,T., Workman,C., Kruhoffer,M., Demtroder,K., Wolf,H., Andersen,L.D., Frederiksen,C.M., Knudsen,S., Orntoft,T.F. Identification of gene expression patterns in superficial and invasive human bladder cancer. Cancer Res.. 61(6): 2492-2499. 2001. PubMed

Xiao,J., Gregersen,S., Kruhoffer,M., Pedersen,S.B., Orntoft,T.F., Hermansen,K. The effect of chronic exposure to fatty acids on gene expression in clonal insulin-producing cells: studies using high density oligonucleotide microarray. Endocrinology. 142(11): 4777-4784. 2001. PubMed

Celis,J.E., Kruhoffer,M., Gromova,I., Frederiksen,C., Ostergaard,M., Thykjaer,T., Gromov,P., Yu,J., Palsdottir,H., Magnusson,N., Orntoft,T.F. Gene expression profiling: monitoring transcription and translation products using DNA microarrays and proteomics. FEBS Lett.. 480(1): 2-16. 2000. PubMed

Hirsch,J.R., Meyer,M., Magert,H.J., Forssmann,W.G., Mollerup,S., Herter,P., Weber,G., Cermak,R., nkorina-Stark,I., Schlatter,E., Kruhoffer,M. cGMP-dependent and -independent inhibition of a K+ conductance by natriuretic peptides: molecular and functional studies in human proximal tubule cells. J Am.Soc.Nephrol.. 10(3): 472-480. 1999. PubMed

John,M., Wiedenmann,B., Kruhoffer,M., Adermann,K., nkorina-Stark,I., Schlatter,E., hnert-Hilger,G., Forssmann,W.G., Kuhn,M. Guanylin stimulates regulated secretion from human neuroendocrine pancreatic cells. Gastroenterology. 114(4): 791-797. 1998. PubMed

Meyer,U., Kruhoffer,M., Flugge,G., Fuchs,E. Cloning of glucocorticoid receptor and mineralocorticoid receptor cDNA and gene expression in the central nervous system of the tree shrew (Tupaia belangeri). Brain Res.Mol.Brain Res.. 55(2): 243-253. 1998. PubMed

Hass,R., Prudovsky,I., Kruhoffer,M. Differential effects of phorbol ester on signaling and gene expression in human leukemia cells. Leuk.Res.. 21(7): 589-594. 1997. PubMed

Hirsch,J.R., Cermak,R., Forssmann,W.G., Kleta,R., Kruhoffer,M., Kuhn,M., Schafer,J.A., Sun,D., Schlatter,E. Effects of sodium nitroprusside in the rat cortical collecting duct are independent of the NO pathway. Kidney Int.. 51(2): 473-476. 1997. PubMed

Kruhoffer,M., Bub,A., Cieslak,A., Adermann,K., Kunstyr,I., Forssmann,W., Magert,H. Gene expression of aphrodisin in female hamster genital tract segments. Cell Tissue Res.. 287(1): 153-160. 1997. PubMed

Meyer,M., Fluge,T., Kruhoffer,M., Forssmann,W.G. Basic aspects of vasorelaxant and bronchodilating peptides in clinical use: urodilatin (INN: Ularitide), VIP, and PACAP. Ann.N Y.Acad.Sci.. 805(077-8923): 443-461. 1996. PubMed

Kruhoffer,M., Urbanke,C., Grosse,F. Two step binding of HIV-1 reverse transcriptase to nucleic acid substrates. Nucleic Acids Res.. 21(17): 3943-3949. 1993. PubMed

Austermann,S., Kruhoffer,M., Grosse,F. Inhibition of human immunodeficiency virus type 1 reverse transcriptase by 3'-blocked oligonucleotide primers. Biochem.Pharmacol.. 43(12): 2581-2589. 1992. PubMed

Hubner,A., Kruhoffer,M., Grosse,F., Krauss,G. Fidelity of human immunodeficiency virus type I reverse transcriptase in copying natural RNA. J Mol.Biol.. 223(3): 595-600. 1992. PubMed

Heidenreich,O., Kruhoffer,M., Grosse,F., Eckstein,F. Inhibition of human immunodeficiency virus 1 reverse transcriptase by 3'-azidothymidine triphosphate. Eur.J Biochem.. 192(3): 621-625. 1990. PubMed

Kruhoffer,M., Glass,M.L., Abe,A.S., Johansen,K. Control of breathing in an amphibian Bufo paracnemis: effects of temperature and hypoxia. Respir.Physiol. 69(2): 267-275. 1987. PubMed